Evidence map›Paper›PMID 39150407›Full record

ReviewChemSusChem2025

Enzymatic Degradation of PFAS: Current Status and Ongoing Challenges.

Benjamin A Harris, Jinpeng Zhou, Bradley O Clarke, Ivanhoe K H Leung

Abstract readReview
In one paragraph

Review in ChemSusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Benjamin A HarrisSchool of Chemistry and Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Jinpeng ZhouSchool of Chemistry and Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0009-0009-5490-1991
Bradley O ClarkeAustralian Laboratory for Emerging Contaminants, School of Chemistry, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0002-4559-9585
Ivanhoe K H LeungSchool of Chemistry and Bio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0003-0633-6771

Funding

Selby Scientific Foundation Selby Research AwardThe University of Melbourne Norma Hilda Schuster (nee Swift) Scholarship
6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFAS) are often considered the quintessential example of industrial chemical pollution - they are toxic and ubiquitous environmental contaminants that are extremely difficult to degrade. There has been a large research focus on the development of effective and renewable degradation technologies. In comparison to traditional pollutant degradation techniques, such as advanced oxidation processes and electrochemistry, degradation of PFAS using extracellular enzymes offers an eco-friendly solution as enzymes are biodegradable, recyclable and have low energy and chemical requirements. This review outlines the current understanding of extracellular enzymatic degradation of PFAS with a focus on reported results and proposed degradation mechanisms. More importantly, this review highlights limitations that hinder the application of enzymes for PFAS degradation and proposes critical future research that is needed to improve the applicability of this promising remediation strategy.

Indexed as

Environmental PollutantsEnzymesFluorocarbonsBiodegradation, EnvironmentalEnvironmental PollutantsEnzymesFluorocarbonsBioremediationDefluorinationEnzymatic degradationEnzymesPFASSustainable chemistry

Identifiers

PMID39150407
PMCPMC11739852

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.