Evidence map›Paper›PMID 39150246›Full record

ArticlemBio2024

Constitutive upregulation of transcription factors underlies permissive bradyzoite differentiation in a natural isolate of

Jing Xia, Yong Fu, Wanyi Huang, Taher Uddin, L David Sibley

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Improved Bicyclic Pyrrolidine Analogues InhibitJournal of medicinal chemistry · 2025
    Article
  5. Role ofInternational journal of molecular sciences · 2025
    Article
  6. Article
  7. Novel Drug Targets for the Bradyzoite Form ofResearch and reports in tropical medicine · 2025
    Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jing XiaDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-7590-4544
Yong FuDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-7590-4544
Wanyi HuangDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Taher UddinDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
L David SibleyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-7110-0285

Funding

Optimizing CDPK1 inhibitors for chronic toxoplasmosisR01AI164473 · NIAID · WASHINGTON UNIVERSITY · PI James W Janetka, L. David Sibley · 2022 to 2026
$3.9M
Regulation of host cell egress by Toxoplasma gondiiR01AI162749 · NIAID · WASHINGTON UNIVERSITY · PI SIBLEY, L. DAVID · 2022 to 2025
$3.1M
NIAID NIH HHS R01 AI162749NIAID NIH HHS R01 AI164473
6 · The paper itself

Abstract

IMPORTANCE:

Indexed as

Protozoan ProteinsToxoplasmaTranscription FactorsAnimalsFibroblastsGene Expression ProfilingHumansLife Cycle StagesMiceToxoplasmosisUp-RegulationProtozoan ProteinsTranscription FactorsApetala 2 transcription factorChronic infectionstress-induced differentiationtissue cyst

Identifiers

PMID39150246
PMCPMC11389365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.