Evidence map›Paper›PMID 39150237›Full record

ArticleHead & neck2025

Effects of chemoradiation and tongue exercise on swallow biomechanics and bolus kinematics.

Nicole E Schaen-Heacock, Linda M Rowe, Michelle R Ciucci, John A Russell

Abstract read
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In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicole E Schaen-HeacockDepartment of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-8053-7953
Linda M RoweDepartment of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Michelle R CiucciDepartment of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, Wisconsin, USA.
John A RussellDivision of Otolaryngology, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Funding

Preclinical trial for dysarthria treatment in Parkinson diseaseR01DC018584 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI CIUCCI, MICHELLE RENEE · 2021 to 2025
$3.3M
Treatment of Functional Deficits IN tongue muscles induced by radiation and chemoradiation treatmentR37CA225608 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI RUSSELL, JOHN A · 2018 to 2024
$2.4M
Effects of chronic use of thickened liquids in a rat model of agingF31AG077952 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ROWE, LINDA M · 2022 to 2023
$93k
National Institute of Health, National Cancer Institute (NIH NCI) 5R37CA225608-07National Institute of Health, National Institute on Aging (NIH, NIA) F31AG077952-01National Institute of Health, National Institute on Deafness and Other Communication Disorders (NIH, NIDCD) R01DC018584-01NCI NIH HHS R37 CA225608NIA NIH HHS F31 AG077952NIDCD NIH HHS R01 DC018584
6 · The paper itself

Abstract

backgroundCommon treatments for head and neck cancer (radiation and chemotherapy) can lead to dysphagia; tongue exercise is a common intervention. This study aimed to assess swallow biomechanics and bolus kinematics using a well-established rat model of radiation or chemoradiation treatment to the tongue base, with or without tongue exercise intervention.

methodsPre- and post-treatment videofluoroscopy was conducted on 32 male Sprague-Dawley rats treated with radiation/chemoradiation and exercise/no exercise. Rats in the exercise groups completed a progressive resistance tongue training paradigm. Swallow biomechanics, bolus kinematics, jaw opening, and post-swallow respiration were assessed.

resultsBoth treatments impacted outcome measures; the addition of exercise intervention showed benefit for some measures, particularly in rats treated with radiation, vs. chemoradiation.

conclusionsRadiation and chemoradiation can significantly affect aspects of deglutition; combined treatment may result in worse outcomes. Tongue exercise intervention can mitigate deficits; more intensive intervention may be warranted in proportion to combined treatment.

Indexed as

ChemoradiotherapyDeglutitionDeglutition DisordersRats, Sprague-DawleyTongueAnimalsBiomechanical PhenomenaDisease Models, AnimalFluoroscopyHead and Neck NeoplasmsMalePhysical Conditioning, AnimalRatschemoradiationdeglutitiondysphagiamurineradiation

Identifiers

PMID39150237
PMCPMC11635752

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.