ArticleCureus2024
Serum Tumor Necrosis Factor Alpha (TNF-α) Levels in Obese and Overweight Adults: Correlations With Metabolic Syndrome and Inflammatory Markers.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Almond Consumption Improves Inflammatory Profiles Independent of Weight Change: A 6-Week Randomized Controlled Trial in Adults with Obesity.Nutrients · 2026Trial
- Review
- The Degree of Liver Steatosis Is Associated with Abnormally High Serum Levels of Markers of Blood-Brain Barrier Dysfunction and Systemic Inflammation in Patients with Morbid Obesity.Medicina (Kaunas, Lithuania) · 2026Article
- Obesity supersizes macrophage and neutrophil activation after stroke while lipid droplets play a protective role.Journal of neuroinflammation · 2026Article
- A Contemporary Perspective on Long-Term Complications of Bariatric Surgery.Obesity surgery · 2026Review
- Associations of tumor necrosis factor alpha genetic variants with metabolic syndrome and type 2 diabetes mellitus in a Thai population.PloS one · 2026Article
- Obesity and type 2 diabetes as chronic inflammation: how does the cytokine evidence align?Frontiers in endocrinology · 2026Review
- Construction of a nomogram prediction model for obstructive sleep apnea combined with hypertension via polysomnography: a single-center retrospective study.European journal of medical research · 2025Article
- The Linkage Between Inflammation and the Progression of Type 2 Diabetes Mellitus.Current issues in molecular biology · 2025Article
- Tectoridin modulates intertwined molecular pathways in metabolic syndrome: insights from network pharmacology, molecular docking, and in vivo studies.Inflammopharmacology · 2025Article
- Atorvastatin Confers Renoprotection and Modulates Inflammation in Diabetic Rats on a High-Fat Diet.Life (Basel, Switzerland) · 2025Article
- Unraveling the complexities of diet induced obesity and glucolipid dysfunction in metabolic syndrome.Diabetology & metabolic syndrome · 2025Review
- Molecular crosstalk in perivascular adipose tissue: mechanisms of inflammation, metabolic dysregulation, and therapeutic opportunities in cardiovascular disease.Frontiers in cardiovascular medicine · 2025Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOverweight and obesity are escalating public health concerns globally, and India is also experiencing a significant rise in the population of overweight and obese people. Tumour necrosis factor alpha (TNF-α) is a type of cytokine that has garnered attention in particularly obesity-related metabolic disturbances. This study aimed to assess TNF-α levels in overweight and obese adults and explore its correlation with metabolic syndrome and associated biochemical parameters in the northeastern Indian population.
methodsA comparative study was conducted involving 200 participants divided into four groups: 50 healthy controls, 50 overweight individuals, 50 obese individuals without metabolic syndrome and 50 obese individuals with metabolic syndrome. Serum TNF-α levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Anthropometric measurements and biochemical analyses, including glucose and lipid profiles, were performed using standard methods.
resultsTNF-α levels were significantly elevated in overweight individuals (128.5±35.7 pg/ml), obese individuals without metabolic syndrome (171.5±13.6 pg/ml), and obese individuals with metabolic syndrome (238.6±62 pg/ml) compared to normal subjects (controls; 21.7±11.8 pg/ml). Positive correlations were observed between TNF-α and body mass index (BMI), waist-to-hip ratio (WHR), neck circumference, glucose, cholesterol, triglycerides, and negative correlation was found high-density lipoprotein cholesterol (HDL-C).
conclusionElevated TNF-α levels in overweight and obese individuals suggest its role in metabolic disturbances and immune activation within the adipose tissue. These findings underscore the importance of monitoring TNF-α as a potential biomarker for metabolic syndrome risk, highlighting the need for targeted interventions in the northeastern Indian population to mitigate the health impacts of obesity and associated metabolic disorders.
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