Evidence map›Paper›PMID 39149504›Full record

ArticleResearch square2024

Bi-specific antibody engagers for cancer immunotherapy.

Hidde Ploegh, Xin Liu, Camille Le Gall, Ryan Alexander, Ella Borgman, Thomas Balligand

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Hidde PloeghBoston Children's Hospital.ORCID https://orcid.org/0000-0002-1090-6071
Xin LiuBoston Children's Hospital.
Camille Le GallRadboud Institute for Molecular Life Sciences, Radboud University Medical Center.ORCID https://orcid.org/0000-0002-5890-5115
Ryan AlexanderBoston Children's Hospital, Harvard Medical School.
Ella BorgmanBoston Children's Hospital, Harvard Medical School.
Thomas BalligandBoston Children's Hospital, Harvard Medical School.

Funding

Imposing order on the family of ubiquitin-conjugating (E2) enzymes through intracellular perturbation with nanobodiesDP1AI150593 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PLOEGH, HIDDE L. · 2019 to 2023
$7.1M
NIAID NIH HHS DP1 AI150593
6 · The paper itself

Abstract

Bispecific antibody engagers are fusion proteins composed of a nanobody that recognizes immunoglobulin kappa light chains (

Identifiers

PMID39149504
PMCPMC11326407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.