Evidence map›Paper›PMID 39149386›Full record

ArticlebioRxiv : the preprint server for biology2024

Evidence for S

Emily G Saccuzzo, Alicia S Robang, Yuan Gao, Bo Chen, Raquel L Lieberman, Anant K Paravastu

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emily G SaccuzzoSchool of Chemistry & Biochemistry and Georgia Institute of Technology, Atlanta, GA.
Alicia S RobangSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA.
Yuan GaoSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA.
Bo ChenDepartment of Physics, University of Central Florida, Orlando, FL.
Raquel L LiebermanSchool of Chemistry & Biochemistry and Georgia Institute of Technology, Atlanta, GA.ORCID 0000-0001-9345-3735
Anant K ParavastuSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA.ORCID 0000-0001-7183-1942

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Request for Supplement to Promote Diversity in Health Related ResearchR01EY021205 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Raquel L Lieberman · 2011 to 2026
$6.8M
VIsion Science Training in AtlantaT32EY007092 · NEI · EMORY UNIVERSITY · PI Machelle T. Pardue · 1985 to 2026
$4.6M
Characterizing Alzheimer's Amyloid-beta Oligomer Structures by Solid-State NMR and Cryo-Electron MicroscopyRF1AG073434 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI PARAVASTU, ANANT KRISHNA, ROSENBERRY, TERRONE L · 2022 to 2022
$1.6M
NCATS NIH HHS UL1 TR000454NEI NIH HHS R01 EY021205NEI NIH HHS T32 EY007092NIA NIH HHS RF1 AG073434
6 · The paper itself

Abstract

Myocilin-associated glaucoma is a protein-conformational disorder associated with formation of a toxic amyloid-like aggregate. Numerous destabilizing single point variants, distributed across the myocilin olfactomedin β-propeller (OLF, myocilin residues 245-504, 30 kDa) are associated with accelerated disease progression.

Indexed as

amyloid fibrilsglaucomaProtein misfoldingproteostasissolid-state nuclear magnetic resonance spectroscopy

Identifiers

PMID39149386
PMCPMC11326258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.