Evidence map›Paper›PMID 39149359›Full record

ArticlebioRxiv : the preprint server for biology2025

Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes.

Yue Liu, Shilpa Rao, Ian Hoskins, Michael Geng, Qiuxia Zhao, Jonathan Chacko, Vighnesh Ghatpande, Kangsheng Qi, Logan Persyn, Jun Wang and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Yue LiuDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Shilpa RaoDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Ian HoskinsDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Michael GengDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Qiuxia ZhaoDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-9981-268X
Jonathan ChackoDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Vighnesh GhatpandeDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Kangsheng QiDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Logan PersynDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Jun WangmRNA Center of Excellence, Sanofi, Waltham, MA 02451, USA.
Dinghai ZhengmRNA Center of Excellence, Sanofi, Waltham, MA 02451, USA.
Yochen ZhongDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Dayea ParkDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Elif Sarinay CenikDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Vikram AgarwalmRNA Center of Excellence, Sanofi, Waltham, MA 02451, USA.
Hakan OzadamDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Can CenikDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-6370-0889

Funding

Role of Nucleolus and Ribosomes in Organismal Growth and HomeostasisR35GM138340 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Elif Sarinay Cenik · 2020 to 2026
$2.4M
Single cell quantification of translation control in early mouse developmentR35GM150667 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Can Cenik · 2023 to 2026
$1.6M
Translational regulation of limb bud initiationR21HD110096 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI CENIK, CAN, VOKES, STEVEN ALEXANDER · 2022 to 2023
$436k
NICHD NIH HHS R21 HD110096NIGMS NIH HHS R35 GM138340NIGMS NIH HHS R35 GM150667
6 · The paper itself

Abstract

Characterizing shared patterns of RNA expression between genes across conditions has led to the discovery of regulatory networks and novel biological functions. However, it is unclear if such coordination extends to translation. Here, we uniformly analyzed 3,819 ribosome profiling datasets from 117 human and 94 mouse tissues and cell lines. We introduce the concept of

Indexed as

Gene functionsRegulatory networksRibosome profilingTranslational regulationTranslation efficiencyTranslation efficiency covariation

Identifiers

PMID39149359
PMCPMC11326257

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.