Evidence map›Paper›PMID 39149330›Full record

ArticlebioRxiv : the preprint server for biology2024

Bryan T Murphy, Jacob J Wiepen, Danielle E Graham, Selene K Swanson, Maithri M Kashipathy, Anne Cooper, Kevin P Battaile, David K Johnson, Laurence Florens, Jon S Blevins and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bryan T MurphyUniversity of Kansas School of Medicine, Department of Microbiology, Molecular Genetics & Immunology, Kansas City, Kansas.
Jacob J WiepenUniversity of Kansas School of Medicine, Department of Microbiology, Molecular Genetics & Immunology, Kansas City, Kansas.
Danielle E GrahamUniversity of Arkansas for Medical Sciences, Department of Microbiology & Immunology, Little Rock, Arkansas.
Selene K SwansonStowers Institute, Kansas City, Missouri.
Maithri M KashipathySeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, 98109, USA.
Anne CooperSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, 98109, USA.
Kevin P BattaileNew York Structural Biology Center, Upton, New York.
David K JohnsonUniversity of Kansas, Protein Structure and X-ray Crystallography Laboratory, Lawrence, Kansas.
Laurence FlorensStowers Institute, Kansas City, Missouri.
Jon S BlevinsUniversity of Arkansas for Medical Sciences, Department of Microbiology & Immunology, Little Rock, Arkansas.ORCID 0000-0001-6216-7365
Scott LovellSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, 98109, USA.
Wolfram R ZückertUniversity of Kansas School of Medicine, Department of Microbiology, Molecular Genetics & Immunology, Kansas City, Kansas.ORCID 0000-0002-7350-2162

Funding

Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9M
Centers for Research on Structural Biology of Infectious Diseases: Universal Influenza Vaccine Research75N93022C00036 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI STAKER, BART · 2022 to 2025
$21.7M
Study of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5M
Protein Structure Laboratory P30GM110761 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HANZLIK, ROBERT P · 2014 to 2018
$5.6M
The University of Arkansas for Medical Sciences Initiative for Maximizing Student Development ProgramR25GM083247 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI MCGEHEE, ROBERT E, THOMAS, BILLY R · 2009 to 2023
$5.4M
RpoS-mediated virulence regulation in Borrelia burgdorferiR01AI087678 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI BLEVINS, JON SCOTT · 2010 to 2014
$1.8M
An Eiger2 XE 9M detector for the NYSBC-operated NYX beamline at NSLS-IIS10OD030394 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI BATTAILE, KEVIN P · 2021 to 2021
$1.8M
Lipoprotein Transport in Borrelia SpirochetesR01AI063261 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ZUECKERT, WOLFRAM R · 2006 to 2010
$1.8M
Role of Borrelia Lpt Homologs in Surface Lipoprotein SecretionR21AI173835 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ZUECKERT, WOLFRAM R · 2023 to 2024
$426k
Chaperone-Mediated Secretion of Borrelia LipoproteinsR21AI144624 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ZUECKERT, WOLFRAM R · 2019 to 2020
$413k
Rrp2-dependent gene regulation in Borrelia burgdorferiR21AI119532 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI BLEVINS, JON SCOTT · 2015 to 2016
$403k
NIAID NIH HHS 75N93022C00036NIAID NIH HHS L70 AI178835NIAID NIH HHS R01 AI063261NIAID NIH HHS R01 AI087678NIAID NIH HHS R21 AI119532NIAID NIH HHS R21 AI144624NIAID NIH HHS R21 AI173835NIGMS NIH HHS P20 GM103625NIGMS NIH HHS P20 GM113117NIGMS NIH HHS P30 GM110761NIGMS NIH HHS R25 GM083247NIH HHS S10 OD030394
6 · The paper itself

Abstract

In diderm bacteria, the Lol pathway canonically mediates the periplasmic transport of lipoproteins from the inner membrane (IM) to the outer membrane (OM) and therefore plays an essential role in bacterial envelope homeostasis. After extrusion of modified lipoproteins from the IM via the LolCDE complex, the periplasmic chaperone LolA carries lipoproteins through the periplasm and transfers them to the OM lipoprotein insertase LolB, itself a lipoprotein with a LolA-like fold. Yet, LolB homologs appear restricted to γ-proteobacteria and are missing from spirochetes like the tick-borne Lyme disease pathogen

Identifiers

PMID39149330
PMCPMC11326224

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.