Evidence map›Paper›PMID 39149326›Full record

ArticlebioRxiv : the preprint server for biology2024

Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk.

Hannah M Mummey, Weston Elison, Katha Korgaonkar, Ruth M Elgamal, Parul Kudtarkar, Emily Griffin, Paola Benaglio, Michael Miller, Alokkumar Jha, Jocelyn E Manning Fox and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hannah M MummeyBioinformatics and Systems Biology Program, University of California San Diego, La Jolla CA.
Weston ElisonBiomedical Sciences Program, University of California San Diego, La Jolla CA, USA.
Katha KorgaonkarDepartment of Pediatrics, University of California San Diego, La Jolla CA, USA.
Ruth M ElgamalBiomedical Sciences Program, University of California San Diego, La Jolla CA, USA.
Parul KudtarkarDepartment of Pediatrics, University of California San Diego, La Jolla CA, USA.
Emily GriffinDepartment of Pediatrics, University of California San Diego, La Jolla CA, USA.
Paola BenaglioDepartment of Pediatrics, University of California San Diego, La Jolla CA, USA.
Michael MillerCenter for Epigenomics, University of California San Diego, La Jolla CA, USA.
Alokkumar JhaDepartment of Pediatrics, Stanford School of Medicine, Stanford University, Stanford CA, USA.ORCID 0000-0002-8024-5854
Jocelyn E Manning FoxDepartment of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.
Mark I McCarthyWellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK*.ORCID 0000-0002-4393-0510
Sebastian PreisslCenter for Epigenomics, University of California San Diego, La Jolla CA, USA.
Anna L GloynDepartment of Pediatrics, Stanford School of Medicine, Stanford University, Stanford CA, USA.ORCID 0000-0003-1205-1844
Patrick E MacDonaldAlberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Kyle J GaultonDepartment of Pediatrics, University of California San Diego, La Jolla CA, USA.

Funding

The Human Pancreas Analysis Program for Type 2 DiabetesU01DK123594 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Robert Babak Faryabi, KLAUS H KAESTNER · 2019 to 2026
$25.0M
The next iteration of the AMP-T2D Knowledge PortalUM1DK105554 · NIDDK · BROAD INSTITUTE, INC. · PI BOEHNKE, MICHAEL L, BURTT, NOEL P · 2020 to 2025
$18.5M
Penn integrated Human Pancreas procurement and Analysis ProgramUC4DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R, FELDMAN, MICHAEL D · 2016 to 2020
$17.8M
Proposal for the AMP T2D-GENES Data Coordination Center and Web PortalU01DK105554 · NIDDK · BROAD INSTITUTE, INC. · PI FLOREZ, JOSE CARLOS · 2015 to 2019
$16.8M
An interactive resource to generate and provide integrated knowledge of the human pancreasU24DK138512 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Noel P Burtt, Jason Flannick · 2024 to 2026
$9.6M
Training Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6M
Supplement to Integrated Program for Human Pancreas Procurement and AnalysisUC4DK112232 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ATKINSON, MARK A., POWERS, ALVIN C · 2016 to 2020
$8.4M
The impact of genomic variation on environment-induced changes in pancreatic beta cell statesU01HG012059 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hannah Kathryn Carter, Kyle Jeffrie Gaulton · 2021 to 2026
$7.5M
Human Pancreas Analysis Program-T2DU01DK123716 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ATKINSON, MARK A., BOTTINO, RITA · 2019 to 2024
$6.6M
UC San Diego Genetics Training ProgramT32GM145427 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRUCE A HAMILTON · 2022 to 2026
$2.6M
NHGRI NIH HHS U01 HG012059NIDDK NIH HHS U01 DK105554NIDDK NIH HHS U01 DK123594NIDDK NIH HHS U01 DK123716NIDDK NIH HHS U24 DK138512NIDDK NIH HHS UC4 DK112217NIDDK NIH HHS UC4 DK112232NIDDK NIH HHS UM1 DK105554NIGMS NIH HHS T32 GM008666NIGMS NIH HHS T32 GM145427
6 · The paper itself

Abstract

Physiological variability in pancreatic cell type gene regulation and the impact on diabetes risk is poorly understood. In this study we mapped gene regulation in pancreatic cell types using single cell multiomic (joint RNA-seq and ATAC-seq) profiling in 28 non-diabetic donors in combination with single cell data from 35 non-diabetic donors in the Human Pancreas Analysis Program. We identified widespread associations with age, sex, BMI, and HbA1c, where gene regulatory responses were highly cell type- and phenotype-specific. In beta cells, donor age associated with hypoxia, apoptosis, unfolded protein response, and external signal-dependent transcriptional regulators, while HbA1c associated with inflammatory responses and gender with chromatin organization. We identified 10.8K loci where genetic variants were QTLs for

Identifiers

PMID39149326
PMCPMC11326183

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.