Evidence map›Paper›PMID 39149297›Full record

ArticlebioRxiv : the preprint server for biology2024

Turning a Kv channel into hot and cold receptor by perturbing its electromechanical coupling.

Bernardo I Pinto-Anwandter, Carlos A Z Bassetto, Ramon Latorre, Francisco Bezanilla

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Bernardo I Pinto-AnwandterDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0003-0200-1069
Carlos A Z BassettoDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0002-7012-5699
Ramon LatorreCentro Interdisciplinario de Neurociencias de Valparaiso, Universidad de Valparaiso, Valparaiso, Chile.ORCID 0000-0002-6044-5795
Francisco BezanillaDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0002-6663-7931

Funding

The Electrophysiological Studies of Voltage Gated ChannelsR01GM030376 · NIGMS · UNIVERSITY OF CHICAGO · PI BEZANILLA, FRANCISCO J · 1985 to 2025
$9.1M
NIGMS NIH HHS R01 GM030376
6 · The paper itself

Abstract

Voltage-dependent potassium channels (Kv) are extremely sensitive to membrane voltage and play a crucial role in membrane repolarization during action potentials. Kv channels undergo voltage-dependent transitions between closed states before opening. Despite all we have learned using electrophysiological methods and structural studies, we still lack a detailed picture of the energetics of the activation process. We show here that even a single mutation can drastically modify the temperature response of the

Identifiers

PMID39149297
PMCPMC11326270

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.