Evidence map›Paper›PMID 39149276›Full record

ArticlebioRxiv : the preprint server for biology2024

Sex-specific behavioral and thalamo-accumbal circuit adaptations after oxycodone abstinence.

Y Alonso-Caraballo, Y Li, N J Constantino, M A Neal, G S Driscoll, M Mavrikaki, V Y Bolshakov, E H Chartoff

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Y Alonso-CaraballoDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.ORCID 0000-0002-7553-4408
Y LiDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
N J ConstantinoDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
M A NealDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
G S DriscollDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
M MavrikakiDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
V Y BolshakovDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
E H ChartoffDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.ORCID 0000-0002-1657-694X

Funding

SPARED CenterP50MH115874 · NIMH · MCLEAN HOSPITAL · PI CARLEZON, WILLIAM A. · 2019 to 2023
$13.7M
Cell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala PathwaysR01MH108665 · NIMH · MCLEAN HOSPITAL · PI BOLSHAKOV, VADIM, RESSLER, KERRY J. · 2016 to 2025
$7.5M
Synaptic and neuronal mechanisms of fear control: the role of hippocampal-amygdalar interactionsR01MH123993 · NIMH · MCLEAN HOSPITAL · PI BOLSHAKOV, VADIM · 2020 to 2024
$2.5M
Neurobiological mechanisms of prescription opioid withdrawalR01DA045000 · NIDA · MCLEAN HOSPITAL · PI CHARTOFF, ELENA H · 2017 to 2021
$2.1M
Role of the estrous cycle and nucleus accumbens signaling on incubation of oxycodone craving in female ratsK00DA053527 · NIDA · UNIVERSITY OF MINNESOTA · PI ALONSO CARABALLO, YANAIRA · 2020 to 2023
$335k
NIDA NIH HHS K00 DA053527NIDA NIH HHS R01 DA045000NIMH NIH HHS P50 MH115874NIMH NIH HHS R01 MH108665NIMH NIH HHS R01 MH123993
6 · The paper itself

Abstract

Opioid use disorder is marked by a progressive change in the motivation to administer the drug even in the presence of negative consequences. After long periods of abstinence, the urge to return to taking the drug intensifies over time, known as incubation of craving. Conditioned responses to drug-related stimuli, can acquire motivational properties and exert control over motivated behaviors leading to relapse. Although, preclinical data suggest that the behavioral expression of opioid use is similar between male and female rodents, we do not have conclusive results on sex differences on craving and relapse across abstinence periods. Here, we investigated the effects of abstinence from oxycodone self-administration on neurotransmission in the paraventricular thalamus (PVT) to nucleus accumbens shell (NAcSh) pathway in male and female rats. Using optogenetics and

Indexed as

abstinenceoxycodonerelapsesex differencessynaptic plasticitythalamo-accumbens circuitry

Identifiers

PMID39149276
PMCPMC11326127

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.