Evidence map›Paper›PMID 39149188›Full record

ArticleJPGN reports2024

Optimizing peripubertal growth in a child with short bowel syndrome on full oral feeding with glucagon-like peptide 2 analog.

Anastasiia Romanchuk, Michela Bravi, Paola Tebaldi, Lorenzo D'Antiga, Lorenzo Norsa

Abstract readCase Reports
In one paragraph

Article in JPGN reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anastasiia RomanchukPediatric Hepatology, Gastroenterology and Transplantation, ASST Papa Giovanni XXIII Bergamo Italy.
Michela BraviPediatric Hepatology, Gastroenterology and Transplantation, ASST Papa Giovanni XXIII Bergamo Italy.
Paola TebaldiDepartment of Anatomopathology ASST Papa Giovanni XXIII Bergamo Italy.
Lorenzo D'AntigaPediatric Hepatology, Gastroenterology and Transplantation, ASST Papa Giovanni XXIII Bergamo Italy.ORCID https://orcid.org/0000-0001-7150-3148
Lorenzo NorsaPediatric Hepatology, Gastroenterology and Transplantation, ASST Papa Giovanni XXIII Bergamo Italy.ORCID https://orcid.org/0000-0003-3322-2921

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Teduglutide is a glucagon-like peptide 2 (GLP-2) analog which acts by increasing intestinal absorption of the remnant bowel for children with short bowel syndrome (SBS) dependent on parenteral nutrition. We present a 13-year-old male patient with type 2 SBS (55 cm of jejunum) from necrotizing enterocolitis on full oral feeding from the age of 12 months. Because of faltering growth from the age of 11 despite oral hyperphagia, he started Teduglutide at the standard dose. Eighteen months after Teduglutide start the young boy gained 10 kg in weight and 13 cm in height with a significant reduction in bowel distension. No adverse events were reported during the treatment. Pubertal spurt might be impaired in children with SBS on full oral feeding if the caloric need is not met by the residual intestinal absorption rate. GLP-2 analog might represent an option to sustain pubertal spurt in SBS children on full oral feeding with hyperphagia.

Indexed as

hyperphagiaintestinal failurepubertal spurtteduglutide

Identifiers

PMID39149188
PMCPMC11322011

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.