Evidence map›Paper›PMID 39149144›Full record

ArticleFrontiers in aging neuroscience2024

Matching supplementary motor area-primary motor cortex paired transcranial magnetic stimulation improves motor dysfunction in Parkinson's disease: a single-center, double-blind randomized controlled clinical trial protocol.

Xiaoshun Tang, Zhexue Huang, Guangyue Zhu, Haoyuan Liang, Hui Sun, Yu Zhang, Yalin Tan, Minglong Cui, Haiyan Gong, Xijin Wang and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07434089 (Gut-Brain Axis and Rehabilitation), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07434089 narecruitingnot on this mapstarted 2025, after this paper: background citation

Gut-Brain Axis and Rehabilitation: Study on the Effects of C-Mill Technology on the Intestinal Microbiota of Parkinson's Disease Patients

TypeinterventionalSponsorIRCCS Centro Neurolesi Bonino PulejoRan2025 to 2028Enrolled60ConditionsParkinson DiseaseArmsC-Mill technology treadmill equipped with semi-immersive VR, C-Mill treatment without semi-immersive virtual reality (VR), Conventional physiotherapy training
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaoshun Tang *Department of Neurology, Tongji Hospital, Tongji University, Shanghai, China.
Zhexue Huang *Department of Neurology, Tongji Hospital, Tongji University, Shanghai, China.
Guangyue ZhuDepartment of Rehabilitation, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Haoyuan LiangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Hui SunDepartment of Neurology, Tongji Hospital, Tongji University, Shanghai, China.
Yu ZhangDepartment of Neurology, Tongji Hospital, Tongji University, Shanghai, China.
Yalin TanDepartment of Neurology, Tongji Hospital, Tongji University, Shanghai, China.
Minglong CuiDepartment of Neurology, Tongji Hospital, Tongji University, Shanghai, China.
Haiyan GongDepartment of Neurology, Tongji Hospital, Tongji University, Shanghai, China.
Xijin WangDepartment of Neurology, Tongji Hospital, Tongji University, Shanghai, China.
Yu-Hui ChenDepartment of Neurology, Tongji Hospital, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Non-invasive neuroregulation techniques have been demonstrated to improve certain motor symptoms in Parkinson's disease (PD). However, the currently employed regulatory techniques primarily concentrate on stimulating single target points, neglecting the functional regulation of networks and circuits. The supplementary motor area (SMA) has a significant value in motor control, and its functionality is often impaired in patients with PD. The matching SMA-primary motor cortex (M1) paired transcranial magnetic stimulation (TMS) treatment protocol, which benefits patients by modulating the sequential and functional connections between the SMA and M1, was elucidated in this study. Methods: This was a single-center, double-blind, randomized controlled clinical trial. We recruited 78 subjects and allocated them in a 1:1 ratio by stratified randomization into the paired stimulation ( Discussion: Clinical protocols aimed at single targets using non-invasive neuroregulation techniques often improve only one function. Emphasizing the circuit and network regulation in PD is important for enhancing the effectiveness of TMS rehabilitation. Pairing the regulation of cortical circuits may be a potential treatment method for PD. As a crucial node in motor control, the SMA has direct fiber connections with basal ganglia circuits and complex fiber connections with M1, which are responsible for motor execution. SMA regulation may indirectly regulate the function of basal ganglia circuits. Therefore, the developed cortical pairing stimulation pattern can reshape the control of information flow from the SMA to M1. The novel neuroregulation model designed for this study is based on the circuit mechanisms of PD and previous research results, with a scientific foundation and the potential to be a means of neuroregulation for PD.

Indexed as

clinical trialmotor dysfunctionParkinson’s diseaseSMA-M1 paired stimulationtranscranial magnetic stimulation

Identifiers

PMID39149144
PMCPMC11325724

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.