Evidence map›Paper›PMID 39149090›Full record

ArticleClinical kidney journal2024

Long-term outcomes of patients with IgA nephropathy in the German CKD cohort.

Eleni Stamellou, Jennifer Nadal, Bruce Hendry, Alex Mercer, Claudia Seikrit, Wibke Bechtel-Walz, Matthias Schmid, Marcus J Moeller, Mario Schiffer, Kai-Uwe Eckardt and 3 more

Abstract read
In one paragraph

Article in Clinical kidney journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Albuminuria or proteinuria in glomerular disease and CKD-which one to use?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eleni StamellouDivision of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany.ORCID https://orcid.org/0000-0001-7472-4907
Jennifer NadalDepartment of Medical Biometry, Informatics and Epidemiology, Faculty of Medicine, University Hospital Bonn, Bonn, Germany.
Bruce HendryTravere Therapeutics, San Diego, CA, USA.
Alex MercerJAMCO Pharma Consulting, Stockholm, Sweden.
Claudia SeikritDivision of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Wibke Bechtel-WalzDepartment of Medicine IV, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Matthias SchmidDepartment of Medical Biometry, Informatics and Epidemiology, Faculty of Medicine, University Hospital Bonn, Bonn, Germany.
Marcus J MoellerDivision of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Mario SchifferDepartment of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Kai-Uwe EckardtDepartment of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID https://orcid.org/0000-0003-3823-0920
Rafael KramannDivision of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany.ORCID https://orcid.org/0000-0003-4048-6351
Jürgen FloegeDivision of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany.
GCKD study investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The importance of albuminuria as opposed to proteinuria in predicting kidney outcomes in primary immunoglobulin A nephropathy (IgAN) is not well established. Methods: From 2010 to 2012, 421 patients with biopsy-proven IgAN have been enrolled into the German Chronic Kidney Disease (GCKD) cohort, a prospective observational cohort study ( Results: The mean age of IgAN patients at baseline was 51.6 years (± 13.6) and 67% were male. The patient-reported duration of disease at baseline was 5.9 ± 8.1 years. Baseline median urine albumin:creatinine ratio (UACR) was 0.4 g/g [interquartile range (IQR) 0.1-0.8] and mean eGFR was 52.5 ± 22.4 ml/min/1.73 m Conclusion: In the GCKD IgAN subcohort, more than every fourth patient experienced a CKE event within 6.5 years. Our findings support the use of albuminuria as a surrogate to assess the risk of poor kidney outcomes.

Indexed as

albuminuriaCKDglomerulonephritisIgA nephropathyproteinuria

Identifiers

PMID39149090
PMCPMC11324945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.