Evidence map›Paper›PMID 39148961›Full record

ArticleThe Journal of clinical and aesthetic dermatology2024

Pathological and Immunohistochemical Assessment of Aging of the Abdominal Skin Treated with Carboxytherapy: A Randomized, Split-body Trial.

Nooshin Bagherani, Alireza Ghanadan, Golshan Mirmomeni, Alireza Firooz, Bruce R Smoller, Reza Shojaei, Haniyeh Rafipour, Negin Bagherani, Mansoreh Abdolhosseini, Gholamreza Tavoosidana

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Article in The Journal of clinical and aesthetic dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nooshin BagheraniDr. Bagherani is with the Department of Molecular Medicine, School of Advanced Technologies in Medicine at the Tehran University of Medical Sciences in Tehran, Iran.
Alireza GhanadanDr. Ghanadan is with the Department of Dermatopathology, Razi Hospital and Department of Pathology, Cancer Institute at the Imam Khoemini Hospital Complex in Tehran, Iran.
Golshan MirmomeniMrs. Mirmomeni is with the Hearing Research Center at the Ahvaz Jundishapur University of Medical Sciences in Ahvaz, Iran.
Alireza FiroozDr. Firooz is with the Center for Research & Training in Skin Diseases & Leprosy, Clinical Trial Center at the Tehran University of Medical Sciences in Tehran, Iran.
Bruce R SmollerDr. Smoller is with the Department of Pathology at the University of Rochester School of Medicine and Dentistry in Rochester, NY.
Reza ShojaeiDr. Shojaei is with the Department of Surgery at the Arak University of Medical sciences in Arak, Markazi Province, Iran.
Haniyeh RafipourDr. Rafipour is with the Medical School at the Tehran University of Medical Sciences in Tehran, Iran.
Negin BagheraniDr. Bagherani is with the Department of Cellular Biology, Payam-e-Noor University of Arak in Arak, Iran.
Mansoreh AbdolhosseiniDrs Abdolhosseini and Tavoosidana are with the Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences in Tehran, Iran.
Gholamreza TavoosidanaDrs Abdolhosseini and Tavoosidana are with the Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences in Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Skin aging as a continuous and irreversible process is mainly the result of alterations of function and structure of the dermis. Among the modalities used for treating skin aging, carboxytherapy has been introduced as a safe minimally-invasive method for rejuvenation, reparation, and reconditioning of the skin. Objective: We assessed the efficacy of carboxytherapy for the treatment of intrinsic skin aging through pathological and immunohistochemical (IHC) investigations. Methods: Our study was a split-body, randomized clinical trial on 15 female patients with intrinsic skin aging of the abdomen. Carboxytherapy was performed on one side of the abdomen, weekly for 10 sessions, while the other side was left untreated. Two weeks after the last session, skin biopsies were taken from both sides of the abdomen. Staining with hematoxylin-eosin, Masson-trichrome, and Orcein Giemsa was performed for the assessment of epidermal and dermal thickness, collagen, and elastin organization, respectively. IHC examination was performed for investigation of TGF-β1 and VEGF. Results: Pathological examination showed a significant increase in epidermal and dermal thickness and re-organization of collagens and elastic fibers with carboxytherapy. IHC examinations revealed a significantly increased expression of TGF-β1 and VEGF with carboxytherapy. Conclusion: Our study demonstrated the effectiveness of carboxytherapy in treating and reversing intrinsic aging skin through pathological and IHC studies.

Indexed as

carboxytherapyimmunohistochemistrypathologyskin aging

Identifiers

PMID39148961
PMCPMC11324193

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.