Evidence map›Paper›PMID 39148852›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Lack of weight gain and increased mortality during and after treatment among adults with drug-resistant tuberculosis in Georgia, 2009-2020.

Tsira Chakhaia, Henry M Blumberg, Russell R Kempker, Ruiyan Luo, Nino Dzidzikashvili, Mamuka Chincharauli, Nestan Tukvadze, Zaza Avaliani, Christine Stauber, Matthew J Magee

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In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Tsira ChakhaiaGeorgia State University, Atlanta, GA, USA.
Henry M BlumbergEmory University, Atlanta, GA, USA.
Russell R KempkerEmory University, Atlanta, GA, USA.
Ruiyan LuoGeorgia State University, Atlanta, GA, USA.
Nino DzidzikashviliNational Center for Tuberculosis and Lung Disease, Tbilisi, Georgia.
Mamuka ChincharauliNational Center for Tuberculosis and Lung Disease, Tbilisi, Georgia.
Nestan TukvadzeNational Center for Tuberculosis and Lung Disease, Tbilisi, Georgia.
Zaza AvalianiNational Center for Tuberculosis and Lung Disease, Tbilisi, Georgia.
Christine StauberGeorgia State University, Atlanta, GA, USA.
Matthew J MageeEmory University, Atlanta, GA, USA.

Funding

Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Jeffrey M Collins · 2022 to 2026
$5.8M
Emory-Georgia TB Research Training ProgramD43TW007124 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Nestani Tukvadze · 2004 to 2026
$4.6M
FIC NIH HHS D43 TW007124NIAID NIH HHS P30 AI168386
6 · The paper itself

Abstract

Background: While low body mass index (BMI) is associated with poor tuberculosis (TB) treatment outcomes, the impact of weight gain during TB treatment is unclear. To address this knowledge gap, we assessed if lack of weight gain is associated with all-cause mortality during and after TB treatment. Methods: We conducted a retrospective cohort study among adults with newly diagnosed multi- or extensively drug-resistant (M/XDR) pulmonary TB in Georgia between 2009-2020. The exposure was a change in BMI during the first 3-6 months of TB treatment. All-cause mortality during and after TB treatment was assessed using the National Death Registry. We used competing-risk Cox proportional hazard models to estimate adjusted hazard ratios (aHR) between BMI change and all-cause mortality. Results: Among 720 adult participants, 21% had low BMI (<18.5 kg/m Conclusions: Weight loss during TB treatment (among those with normal baseline BMI) or no weight gain (among those with low baseline BMI) was associated with increased rates of all-cause mortality. Our findings suggest that scaling up weight management interventions among those with M/XDR TB may be beneficial.

Indexed as

Body mass indexchange in BMIpost-TB mortality

Identifiers

PMID39148852
PMCPMC11326334

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.