ArticlemedRxiv : the preprint server for health sciences2024
The Interaction Effects of Sex, Age, APOE and Common Health Risk Factors on Human Brain Functions.
Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
Importance: Nonlinear changes in brain function during aging are shaped by a complex interplay of factors, including sex, age, genetics, and modifiable health risk factors. However, the combined effects and underlying mechanisms of these factors on brain functional connectivity remain poorly understood. Objective: To comprehensively investigate the combined associations of sex, age, Design Setting and Participants: This analysis used data from 36,630 UK Biobank participants, aged 44-81, who were assessed for sex, age, Main Outcomes and Measures: Brain functional connectivities were evaluated through within- and between-network functional connectivities and connectivity strength. Associations between risk factors and brain functional connectivities, including their interaction effects, were analyzed. Results: Hypertension, BMI, and education were the top three influential factors. Sex-specific effects were also observed in interactions involving APOE4 gene, smoking, alcohol consumption, diabetes, BMI, and education. Notably, a negative sex-excessive alcohol interaction showed a stronger negative effect on functional connectivities in males, particularly between the dorsal attention network and the language network, while moderate alcohol consumption appeared to have protective effects. A significant negative interaction between sex and Conclusions and Relevance: The findings highlight significant sex disparities in the associations between age, the
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