Evidence map›Paper›PMID 39148833›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Adenomas from individuals with pathogenic biallelic variants in the

Romy Walker, Jihoon E Joo, Khalid Mahmood, Mark Clendenning, Julia Como, Susan G Preston, Sharelle Joseland, Bernard J Pope, Ana B D Medeiros, Brenely V Murillo and 20 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors.

Romy WalkerColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0001-8948-8417
Jihoon E JooColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0003-3331-5335
Khalid MahmoodColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Mark ClendenningColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0001-9852-2103
Julia ComoColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Susan G PrestonColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Sharelle JoselandColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0003-3481-6801
Bernard J PopeColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0002-4840-1095
Ana B D MedeirosClinical and Functional Genomics Group, International Research Centre/CIPE, A.C. Camargo Cancer Centre, Sao Paulo, 01508-010, Brazil.
Brenely V MurilloGenetic Services of Western Australia, King Edward Memorial Hospital, Perth, WA, 6008, Australia.
Nicholas PachterGenetic Services of Western Australia, King Edward Memorial Hospital, Perth, WA, 6008, Australia.
Kevin SweetDivision of Human Genetics, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Allan D SpigelmanHunter Family Cancer Service, Newcastle, NSW, 2298, Australia.
Alexandra GrovesHunter Family Cancer Service, Newcastle, NSW, 2298, Australia.
Margaret GleesonHunter Family Cancer Service, Newcastle, NSW, 2298, Australia.
Krzysztof BernatowiczAdult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Nicola PoplawskiAdult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Lesley AndrewsHereditary Cancer Centre, Prince of Wales Hospital, Randwick, New South Wales, Australia.
Emma HealeyPrince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Randwick, New South Wales 2031 Australia.
Steven GallingerLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Robert C GrantDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Aung K WinUniversity of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, VIC, 3053, Australia.ORCID 0000-0002-8567-173X
Mark A JenkinsUniversity of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia.
Giovana T TorrezanClinical and Functional Genomics Group, International Research Centre/CIPE, A.C. Camargo Cancer Centre, Sao Paulo, 01508-010, Brazil.
Christophe RostyColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0001-7671-2651
Finlay A MacraeGenomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, 3000, Australia.ORCID 0000-0003-4035-9678
Ingrid M WinshipGenomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, 3000, Australia.
Daniel D BuchananColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0003-2225-6675
Peter GeorgesonColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0002-5096-4735

Funding

Data sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8M
NCI NIH HHS U01 CA167551
6 · The paper itself

Abstract

Background: Colorectal cancers (CRCs) from people with biallelic germline likely pathogenic/pathogenic variants in Methods: Whole-exome sequencing of FFPE tissue and matched blood-derived DNA was performed on 9 adenomas and 15 CRCs from 13 biallelic Results: In biallelic Conclusions: SBS18+SBS36 and SBS30 were enriched in adenomas at comparable proportions observed in CRCs from biallelic

Indexed as

adenomaColorectal cancerhereditary cancer predispositionmutational signatureMUTYHNTHL1SBS18SBS30SBS36variant of uncertain clinical significance

Identifiers

PMID39148833
PMCPMC11326331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.