Evidence map›Paper›PMID 39148597›Full record

ArticleAlpha psychiatry2024

The Role of 3' Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia.

Xiaoyun Guo, Xinqun Luo, Xiaoyi Huang, Yong Zhang, Jiawu Ji, Xiaoping Wang, Kesheng Wang, Jijun Wang, Xinghua Pan, Bin Chen and 2 more

Abstract read
In one paragraph

Article in Alpha psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Phenome-wide association studies betweenFrontiers in psychiatry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoyun GuoShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Xinqun LuoDepartment of Neurosurgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Xiaoyi HuangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yong ZhangInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, China.
Jiawu JiDepartment of Psychiatry, Fujian Medical University Affiliated Fuzhou Neuropsychiatric Hospital, Fuzhou, Fujian, China.
Xiaoping WangDepartment of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Kesheng WangDepartment of Family and Community Health, School of Nursing, Health Sciences Center, West Virginia University, Morgantown, WV, USA.ORCID 0000-0001-7118-3877
Jijun WangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID 0000-0002-6861-1807
Xinghua PanDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou, China.ORCID 0000-0002-7421-8155
Bin ChenDepartment of Cardiovascular Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.
Yunlong TanBeijing Huilongguan Hospital, Peking University Huilongguan School of Clinical Medicine, Beijing, China.ORCID 0000-0002-3522-3912
Xingguang LuoBeijing Huilongguan Hospital, Peking University Huilongguan School of Clinical Medicine, Beijing, China.ORCID 0000-0003-3585-042X

Funding

MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059571 · NIMH · UNIVERSITY OF CHICAGO · PI GEJMAN, PABLO V. · 1999 to 2007
$8.0M
A Genome-Wide Association Study of SchizophreniaU01MH079469 · NIMH · NORTHSHORE UNIVERSITY HEALTHSYSTEM · PI GEJMAN, PABLO V. · 2007 to 2009
$4.4M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH060879 · NIMH · WASHINGTON UNIVERSITY · PI CLONINGER, C. ROBERT · 1999 to 2006
$2.7M
Haplotype Mapping of Chromosome 5 Schizophrenia LocusR01MH071681 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI PURCELL, SHAUN M · 2006 to 2010
$2.6M
Software for the analysis of large-scale genotyping and sequencing studiesR01HG005827 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI PURCELL, SHAUN M · 2010 to 2016
$2.1M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059586 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SILVERMAN, JEREMY M. · 1999 to 2006
$1.9M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH061675 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI LEVINSON, DOUGLAS FREDERICK · 1999 to 2007
$1.8M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059587 · NIMH · EMORY UNIVERSITY · PI AMIN, FAROOQ · 1999 to 2006
$1.8M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059565 · NIMH · UNIVERSITY OF COLORADO DENVER · PI FREEDMAN, ROBERT · 1999 to 2006
$1.7M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059588 · NIMH · UNIVERSITY OF QUEENSLAND · PI MOWRY, BRYAN JOHN · 1999 to 2006
$1.4M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH060870 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI BYERLEY, WILLIAM · 1999 to 2006
$1.3M
Genome-wide Association Study of SchizophreniaU01MH079470 · NIMH · STANFORD UNIVERSITY · PI LEVINSON, DOUGLAS FREDERICK · 2007 to 2009
$1.1M
NHGRI NIH HHS R01 HG005827NIMH NIH HHS R01 MH059565NIMH NIH HHS R01 MH059566NIMH NIH HHS R01 MH059571NIMH NIH HHS R01 MH059586NIMH NIH HHS R01 MH059587NIMH NIH HHS R01 MH059588NIMH NIH HHS R01 MH060870NIMH NIH HHS R01 MH060879NIMH NIH HHS R01 MH061675NIMH NIH HHS R01 MH067257NIMH NIH HHS R01 MH071681NIMH NIH HHS R01 MH081800NIMH NIH HHS U01 MH046276NIMH NIH HHS U01 MH046318NIMH NIH HHS U01 MH079469NIMH NIH HHS U01 MH079470Wellcome Trust
6 · The paper itself

Abstract

Objective: Schizophrenia is often associated with volumetric reductions in cortices and expansions in basal ganglia, particularly the putamen. Recent genome-wide association studies have highlighted the significance of variants in the 3' regulatory region adjacent to the kinectin 1 gene ( Methods: We analyzed 1136 single-nucleotide polymorphisms (SNPs) covering the entire 3' regulatory region in 4 independent dbGaP samples (4604 schizophrenia patients vs. 4884 healthy subjects) and 3 independent Psychiatric Genomics Consortium samples (107 240 cases vs. 210 203 controls) to identify consistent associations. Additionally, we examined the regulatory effects of schizophrenia-associated alleles on Results: The major alleles ( Conclusion: Our findings identify significant and functionally relevant risk alleles in the 3' regulatory region adjacent to

Indexed as

cortexgray matter volumeKTN1putamenschizophreniasubcortical structuresurface areasthickness

Identifiers

PMID39148597
PMCPMC11322729

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.