Evidence map›Paper›PMID 39148545›Full record

ArticleFrontiers in pharmacology2024

Timed sulfonylurea modulation improves locomotor and sensory dysfunction following spinal cord injury.

Guo-Ying Xu, Manjit Maskey, Zizhen Wu, Qing Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guo-Ying XuDepartment of Neurobiology, University of Texas Medical Branch, Galveston, TX, United States.
Manjit MaskeyDepartment of Neurobiology, University of Texas Medical Branch, Galveston, TX, United States.
Zizhen WuDepartment of Neurobiology, University of Texas Medical Branch, Galveston, TX, United States.
Qing YangDepartment of Neurobiology, University of Texas Medical Branch, Galveston, TX, United States.

Funding

(PQ9) A NOVEL MECHANISM OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY AND POTENTIAL TREATMENTR01CA208765 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI YANG, QING · 2016 to 2020
$1.7M
Determining the roles of Ca2+-binding proteins in modulation of hair cell mechanotransductionR00DC016328 · NIDCD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WU, ZIZHEN · 2021 to 2023
$982k
Exploring the role of LHFPL5-associated proteins and Ca2+-binding proteins in hair cell mechanotransductionK99DC016328 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI WU, ZIZHEN · 2018 to 2019
$272k
NCI NIH HHS R01 CA208765NIDCD NIH HHS K99 DC016328NIDCD NIH HHS R00 DC016328
6 · The paper itself

Abstract

Traumatic spinal cord injury (SCI) results in immediate tissue necrosis and delayed secondary expansion of neurological damage, often resulting in lifelong paralysis, neurosensory dysfunction, and chronic pain. Progressive hemorrhagic necrosis (PHN) and excessive excitation are the main sources of secondary neural injury. Recent approaches to attenuate PHN by glibenclamide can improve locomotor function after SCI. However, use of glibenclamide can exacerbate development of SCI-induced chronic pain by inhibiting K

Indexed as

ATP-gated potassium channelschronic paindiazoxideglibenclamidespinal cord injury

Identifiers

PMID39148545
PMCPMC11324438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.