Evidence map›Paper›PMID 39148391›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2024

[Role of reactive oxygen species/silent information regulator 1 in hyperoxia-induced bronchial epithelial cell injury].

Kun Yang, Yue Wu, Rong Zhang, Xiao-Ping Lei, Lan Kang, Wen-Bin Dong

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
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Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Kun YangDepartment of Neonatology, Children's Medical Center, Affiliated Hospital of Southwest Medical University/Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, China.
Yue WuDepartment of Neonatology, Children's Medical Center, Affiliated Hospital of Southwest Medical University/Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, China.
Rong ZhangDepartment of Neonatology, Children's Medical Center, Affiliated Hospital of Southwest Medical University/Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, China.
Xiao-Ping LeiDepartment of Neonatology, Children's Medical Center, Affiliated Hospital of Southwest Medical University/Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, China.
Lan KangDepartment of Neonatology, Children's Medical Center, Affiliated Hospital of Southwest Medical University/Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, China.
Wen-Bin DongDepartment of Neonatology, Children's Medical Center, Affiliated Hospital of Southwest Medical University/Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the effect of reactive oxygen species (ROS)/silent information regulator 1 (SIRT1) on hyperoxia-induced mitochondrial injury in BEAS-2B cells.

methodsThe experiment was divided into three parts. In the first part, cells were divided into H0, H6, H12, H24, and H48 groups. In the second part, cells were divided into control group, H48 group, H48 hyperoxia+SIRT1 inhibitor group (H48+EX 527 group), and H48 hyperoxia+SIRT1 agonist group (H48+SRT1720 group). In the third part, cells were divided into control group, 48-hour hyperoxia+N-acetylcysteine group (H48+NAC group), and H48 group. The ROS kit was used to measure the level of ROS. Western blot and immunofluorescent staining were used to measure the expression levels of SIRT1 and mitochondria-related proteins. Transmission electron microscopy was used to observe the morphology of mitochondria.

resultsCompared with the H0 group, the H6, H12, H24, and H48 groups had a significantly increased fluorescence intensity of ROS (

conclusionsThe ROS/SIRT1 axis is involved in hyperoxia-induced mitochondrial injury in BEAS-2B cells.

Indexed as

BronchiEpithelial CellsHyperoxiaReactive Oxygen SpeciesSirtuin 1Cell LineCells, CulturedHumansMitochondriaReactive Oxygen SpeciesSIRT1 protein, humanSirtuin 1Human bronchial epithelial cellHyperoxiaMitochondrial injuryReactive oxygen speciesSilent information regulator 1

Identifiers

PMID39148391
PMCPMC11334550

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