Evidence map›Paper›PMID 39148136›Full record

ArticleAlzheimer's research & therapy2024

Effects of strategic white matter hyperintensities of cholinergic pathways on basal forebrain volume in patients with amyloid-negative neurocognitive disorders.

Ye Eun Kim, Jae-Sung Lim, Chong Hyun Suh, Hwon Heo, Jee Hoon Roh, E-Nae Cheong, Yoojin Lee, Jae Woo Kim, Jae-Hong Lee

Abstract read
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In one paragraph

Article in Alzheimer's research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ye Eun KimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jae-Sung LimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jaesunglim@amc.seoul.kr.
Chong Hyun SuhDepartment of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Hwon HeoDepartment of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jee Hoon RohDepartment of Biomedical Sciences, Department of Physiology, Korea University College of Medicine, Seoul, Korea.
E-Nae CheongDepartment of Medical Science and Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Yoojin LeeDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jae Woo KimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jae-Hong LeeDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jhlee@amc.seoul.kr.

Funding

the Korea Dementia Research Project through the Korea Dementia Research Center (KDRC), funded by the Ministry of Health & Welfare and Ministry of Science & ICT, Republic of Korea RS-2024-00344521
6 · The paper itself

Abstract

backgroundThe cholinergic neurotransmitter system is crucial to cognitive function, with the basal forebrain (BF) being particularly susceptible to Alzheimer's disease (AD) pathology. However, the interaction of white matter hyperintensities (WMH) in cholinergic pathways and BF atrophy without amyloid pathology remains poorly understood.

methodsWe enrolled patients who underwent neuropsychological tests, magnetic resonance imaging, and

resultsA total of 187 patients were enrolled. The median CHIPS score was 12 [IQR 5.0; 24.0]. The BF volume of the highest CHIPS tertile group (mean ± SD, 3.51 ± 0.49, CHIPSt3) was significantly decreased than those of the lower CHIPS tertile groups (3.75 ± 0.53, CHIPSt2; 3.83 ± 0.53, CHIPSt1; P = 0.02). In the univariable regression analysis, factors showing significant associations with the BF volume were the CHIPSt3 group, age, female, education, diabetes mellitus, smoking, previous stroke history, periventricular WMH, and cerebral microbleeds. In multivariable regression analysis, the CHIPSt3 group (standardized beta [β

conclusionsWe identified a significant correlation between strategic WMH burden in the cholinergic pathway and BF atrophy independently of amyloid positivity and WMH severity. These results suggest a mechanism of cholinergic neuronal loss through the dying-back phenomenon and provide a rationale that strategic WMH assessment may help identify target groups that may benefit from acetylcholinesterase inhibitor treatment.

Indexed as

Basal ForebrainMagnetic Resonance ImagingPositron-Emission TomographyWhite MatterAgedAged, 80 and overAtrophyCognitive DysfunctionFemaleHumansMaleMiddle AgedNeuropsychological TestsAmyloid-negative, vascular cognitive impairmentBasal forebrainCholinergic pathwayNeurodegenerationWhite matter hyperintensities

Identifiers

PMID39148136
PMCPMC11325579

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.