Evidence map›Paper›PMID 39148128›Full record

ArticleTrials2024

Magnesium sulphate to prevent perioperative atrial fibrillation in cardiac surgery: a randomized clinical trial : A protocol description of the PeriOperative Magnesium Infusion to Prevent Atrial fibrillation Evaluated (POMPAE) trial.

Manon Meerman, Marit Buijser, Lettie van den Berg, Anne-Marthe van den Heuvel, Gerard Hoohenkerk, Vincent van Driel, Luuk Munsterman, Roel de Vroege, Michael Bailey, Rinaldo Bellomo and 1 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05669417 (Randomized Controlled Trial of Magnesium Sulfate Versus Placebo on the Prevention of Atrial Fibrillation Post Cardiac Surgery.), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05669417 phase2 / phase3terminatednot on this map

Randomized Controlled Trial of Magnesium Sulfate Versus Placebo on the Prevention of Atrial Fibrillation Post Cardiac Surgery.

TypeinterventionalSponsorHagaZiekenhuisRan2022 to 2023Enrolled265ConditionsAtrial Fibrillation New OnsetArmsMagnesium sulfate
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Can partial cardiac denervation reduce postoperative atrial fibrillation following CABG?Indian journal of thoracic and cardiovascular surgery · 2025
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Manon MeermanDepartment of Intensive Care, HagaZiekenhuis, The Hague, The Netherlands.
Marit BuijserDepartment of Cardiology, HagaZiekenhuis, The Hague, The Netherlands.
Lettie van den BergDepartment of Intensive Care, HagaZiekenhuis, The Hague, The Netherlands.
Anne-Marthe van den HeuvelDepartment of Cardiology, HagaZiekenhuis, The Hague, The Netherlands.
Gerard HoohenkerkDepartment of Cardiothoracic Surgery, HagaZiekenhuis, The Hague, The Netherlands.
Vincent van DrielDepartment of Cardiology, HagaZiekenhuis, The Hague, The Netherlands.
Luuk MunstermanDepartment of Cardiac Anaesthesia, HagaZiekenhui, The Hague, The Netherlands.
Roel de VroegeDepartment of Perfusion, HagaZiekenhuis, The Hague, The Netherlands.
Michael BaileyDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
Rinaldo BellomoDepartment of Intensive Care, Austin Health, Melbourne, Australia.
Jeroen LudikhuizeDepartment of Intensive Care, HagaZiekenhuis, The Hague, The Netherlands. j.ludikhuize@hagaziekenhuis.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative atrial fibrillation (POAF) is a common and potentially serious complication post cardiac surgery. Hypomagnesaemia is common after cardiac surgery and recent evidence indicates that supplementation of magnesium may prevent POAF. We aim to investigate the effectiveness of continuous intravenous magnesium sulphate administration in the perioperative period to prevent POAF as compared to placebo.

methodsThe (POMPAE) trial is a phase 2, single-center, double-blinded randomized superiority clinical study. It aims to assess the impact of perioperative continuous intravenous magnesium administration on the occurrence of cardiac surgery-related POAF. A total of 530 patients will be included. Eligible patients will be randomized in 1:1 ratio to the intervention or placebo group with stratification based on the presence of valvular surgery. The objective of the infusion is to maintain ionized magnesium levels between 1.5 and 2.0 mmol/L. DISCUSSION: The primary outcome measure is the incidence of de novo POAF within the first 7 days following surgery, with censoring at hospital discharge. This trial may generate crucial evidence for the prevention of POAF and reduce clinical adverse events in patients following cardiac surgery.

trial registrationThe POMPAE trial was registered at ClinicalTrials.gov under the following identifier NTC05669417, https://clinicaltrials.gov/ct2/show/NCT05669417 . Registered on December 30, 2022. PROTOCOL VERSION: Version 3.3, dated 13-01-2023.

Indexed as

Atrial FibrillationCardiac Surgical ProceduresMagnesium SulfateClinical Trials, Phase II as TopicDouble-Blind MethodEquivalence Trials as TopicFemaleHumansInfusions, IntravenousMaleMiddle AgedPerioperative CarePostoperative ComplicationsRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeMagnesium SulfateCardiac surgeryMagnesium sulphatePostoperative atrial fibrillationRandomized clinical trial

Identifiers

PMID39148128
PMCPMC11328354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.