Evidence map›Paper›PMID 39147954›Full record

ArticleActa diabetologica2025

Immunometabolic profiling related with gestational diabetes mellitus: a nested case-control study of CD4

Xiaohui Wei, Zhuo Sun, Na Wang, Zequn Deng, Wenyun Li, Tao Ying, Min Wu, Yuwei Liu, Gengsheng He

Abstract read
PubMed Publisher
In one paragraph

Article in Acta diabetologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaohui WeiSchool of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, No.130, Dong'an Road, Xuhui District, Shanghai, 200032, China.
Zhuo SunSchool of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, No.130, Dong'an Road, Xuhui District, Shanghai, 200032, China.
Na WangNursing Department, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, 200011, China.
Zequn DengSchool of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, No.130, Dong'an Road, Xuhui District, Shanghai, 200032, China.
Wenyun LiSchool of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, No.130, Dong'an Road, Xuhui District, Shanghai, 200032, China.
Tao YingSchool of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, No.130, Dong'an Road, Xuhui District, Shanghai, 200032, China.
Min WuSchool of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, No.130, Dong'an Road, Xuhui District, Shanghai, 200032, China.
Yuwei LiuSchool of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, No.130, Dong'an Road, Xuhui District, Shanghai, 200032, China. ywliu@fudan.edu.cn.ORCID http://orcid.org/0000-0002-4541-3824
Gengsheng HeSchool of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, No.130, Dong'an Road, Xuhui District, Shanghai, 200032, China. gshe@shmu.edu.cn.

Funding

National Natural Science Foundation of China Grant Nos. 81773413 and 81861138007Shanghai 3-Year Public Health Action Plan Grant No. GWV-10.1-XK11Shanghai Pujiang Program No. 21PJD005
6 · The paper itself

Abstract

aimsTo investigate immunometabolic associations of CD4

methodsA nested case-control study was conducted comprising 53 pairs of GDM patients and matched controls within a prospective cohort. Metabolomic signatures related to both CD4

resultsHigher levels of Treg cells (OR per SD increment (95%CI): 0.57 (0.34, 0.95), p = 0.031) and increased expression of Foxp3 (OR per SD increment (95%CI): 0.59 (0.35, 0.97), p = 0.039) and GATA3 (OR per SD increment (95%CI): 0.42 (0.25, 0.72), p = 0.002) were correlated with a decreased risk of GDM. Plasma pyruvaldehyde, S-adenosylhomocysteine (SAH), bergapten, and 9-fluorenone mediated the association between Tregs and fasting plasma glucose (FPG), with mediation proportions of 46.9%, 39.6%, 52.4%, and 56.9%, respectively.

conclusionsTreg cells and Foxp3 expressions were inversely associated with GDM risk, with potential metabolic mechanisms involving metabolites such as pyruvaldehyde and SAH.

Indexed as

Blood GlucoseCD4-Positive T-LymphocytesDiabetes, GestationalAdultCase-Control StudiesFemaleForkhead Transcription FactorsHumansPhenotypePregnancyProspective StudiesT-Lymphocytes, RegulatoryBlood GlucoseForkhead Transcription FactorsFOXP3 protein, humanCD4+ T cellsGestational diabetes mellitusMetabolomeNested case-control study

Identifiers

PMID39147954

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.