Evidence map›Paper›PMID 39147896›Full record

ArticleCommunications biology2024

Improving wheat grain composition for human health by constructing a QTL atlas for essential minerals.

Petros P Sigalas, Peter R Shewry, Andrew Riche, Luzie Wingen, Cong Feng, Ajay Siluveru, Noam Chayut, Amanda Burridge, Cristobal Uauy, March Castle and 8 more

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Petros P Sigalas *Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK.ORCID 0000-0001-7069-363X
Peter R Shewry *Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK.ORCID 0000-0001-6205-2517
Andrew RicheRothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK.
Luzie WingenJohn Innes Centre, Norwich, Norfolk, NR4 7UH, UK.ORCID 0000-0002-4682-4764
Cong FengShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518124, China.ORCID 0009-0004-5453-6879
Ajay SiluveruJohn Innes Centre, Norwich, Norfolk, NR4 7UH, UK.
Noam ChayutJohn Innes Centre, Norwich, Norfolk, NR4 7UH, UK.
Amanda BurridgeSchool of Biological Sciences, University of Bristol, Bristol, BS8 1UD, UK.ORCID 0000-0002-0140-5523
Cristobal UauyJohn Innes Centre, Norwich, Norfolk, NR4 7UH, UK.ORCID 0000-0002-9814-1770
March CastleRothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK.
Saroj ParmarRothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK.
Charlie PhilpJohn Innes Centre, Norwich, Norfolk, NR4 7UH, UK.
David SteeleRothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK.
Simon OrfordJohn Innes Centre, Norwich, Norfolk, NR4 7UH, UK.
Michelle Leverington-WaiteJohn Innes Centre, Norwich, Norfolk, NR4 7UH, UK.
Shifeng ChengShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518124, China.
Simon GriffithsJohn Innes Centre, Norwich, Norfolk, NR4 7UH, UK.ORCID 0000-0003-2435-7963
Malcolm J HawkesfordRothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK. malcolm.hawkesford@rothamsted.ac.uk.ORCID 0000-0001-8759-3969

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/X011003/1
6 · The paper itself

Abstract

Wheat is an important source of minerals for human nutrition and increasing grain mineral content can contribute to reducing mineral deficiencies. Here, we identify QTLs for mineral micronutrients in grain of wheat by determining the contents of six minerals in a total of eleven sample sets of three biparental populations from crosses between A.E. Watkins landraces and cv. Paragon. Twenty-three of the QTLs are mapped in two or more sample sets, with LOD scores above five in at least one set with the increasing alleles for sixteen of the QTLs being present in the landraces and seven in Paragon. Of these QTLs, the number for each mineral varies between three and five and they are located on 14 of the 21 chromosomes, with clusters on chromosomes 5A (four), 6A (three), and 7A (three). The gene content within 5 megabases of DNA on either side of the marker for the QTL with the highest LOD score is determined and the gene responsible for the strongest QTL (chromosome 5A for Ca) identified as an ATPase transporter gene (TraesCS5A02G543300) using mutagenesis. The identification of these QTLs, together with associated SNP markers and candidate genes, will facilitate the improvement of grain nutritional quality.

Indexed as

MineralsQuantitative Trait LociTriticumChromosome MappingChromosomes, PlantEdible GrainHumansPolymorphism, Single NucleotideMinerals

Identifiers

PMID39147896
PMCPMC11327371

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.