Evidence map›Paper›PMID 39147825›Full record

ArticleNPJ Parkinson's disease2024

CSF markers of neurodegeneration Alzheimer's and Lewy body pathology in isolated REM sleep behavior disorder.

Amaia Muñoz-Lopetegi, Simone Baiardi, Mircea Balasa, Angela Mammana, Gerard Mayà, Marcello Rossi, Mónica Serradell, Corrado Zenesini, Alice Ticca, Joan Santamaria and 4 more

Abstract read
In one paragraph

Article in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
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  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Amaia Muñoz-LopetegiNeurology Service, Sleep Unit, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
Simone BaiardiIRCCS, Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy.
Mircea BalasaAlzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic Barcelona, Barcelona, Spain.
Angela MammanaIRCCS, Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy.
Gerard MayàNeurology Service, Sleep Unit, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
Marcello RossiIRCCS, Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy.
Mónica SerradellNeurology Service, Sleep Unit, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
Corrado ZenesiniIRCCS, Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy.
Alice TiccaDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Joan SantamariaNeurology Service, Sleep Unit, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
Sofia DellavalleIRCCS, Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy.
Carles GaigNeurology Service, Sleep Unit, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
Alex IranzoNeurology Service, Sleep Unit, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain. airanzo@clinic.cat.ORCID http://orcid.org/0000-0002-5618-8271
Piero ParchiIRCCS, Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy. piero.parchi@unibo.it.ORCID http://orcid.org/0000-0002-9444-9524

Funding

Fundación BBVA (BBVA Foundation) Baselga grant
6 · The paper itself

Abstract

We investigated the biomarker profile of neurodegeneration, Alzheimer's and Lewy body pathology in the CSF of 148 polysomnography-confirmed patients with isolated REM sleep behavior disorder (IRBD), a condition that precedes Parkinson's disease (PD) and dementia with Lewy bodies (DLB). We assessed misfolded α-synuclein (AS) by RT-QuIC assay, amyloid-beta peptides (Aβ

Identifiers

PMID39147825
PMCPMC11327307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.