ArticleNPJ digital medicine2024
Dose-response relationship between computerized cognitive training and cognitive improvement.
Article in NPJ digital medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07788209 (Scaffolding in AI-Empowered Cognitive Training Improves Outcomes in Cognitive Impairment), which is not on this map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Scaffolding in AI-Empowered Cognitive Training Improves Outcomes in Cognitive Impairment: A Real-world Retrospective Cohort Study
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Nurse-led non-pharmacological interventions for cognitive improvement in dementia patients: a systematic review and meta-analysis of randomized controlled trials.Frontiers in aging neuroscience · 2026Pooled it
- Bayesian network meta-analysis of the effects of different cognitive interventions on cognitive function in older adults with cognitive impairment.Frontiers in public health · 2026Pooled it
- Donepezil for cancer-related cognitive impairment: systematic review and meta-analysis.Clinical and experimental medicine · 2025Pooled it
- Does Dosage Drive Durability? A Longitudinal Study on Digital Cognitive Training for Sustained Functional Independence.Geriatrics & gerontology international · 2026Trial
- Effect of Multi-Modal Training in Patients With Mild Cognitive Impairment: A Randomized Controlled Pilot Trial.Medical science monitor : international medical journal of experimental and clinical research · 2026Trial
- A study on the effects of CCRT on cognitive function and blood biomarkers in community-dwelling older adults with MCI.BMC geriatrics · 2026Trial
- A randomized trial showing mnemonic strategy training increases memory, brain activation, and functional connectivity more than vanishing cue training in cognitively intact older adults.Neuropsychological rehabilitation · 2026Trial
- Developing digital biomarker for predicting cognitive response to multi-domain intervention.Scientific reports · 2026Trial
- Effect of Dual-Task Training on Cognitive Function in Community-Dwelling Older Adults With Mild Cognitive Impairment: Sequential Multiple Assignment Randomized Trial.Journal of medical Internet research · 2025Trial
- Active Ingredients in Digital Cognitive Interventions: Integrating Dismantling Designs With Mechanistic Neuroscience.JMIR mental health · 2026Article
- The Role of Inhibitory Control in Moderating Working Memory Training Transfer: Evidence from a Preregistered Trial with Older Adults.Research square · 2026Article
- Usability and feasibility of INFORMA platform for computerized cognitive stimulation in mild cognitive impairment and early dementia: an 8-week multicenter study.Aging clinical and experimental research · 2026Article
- Meta-analysis of computerised working memory training: behavioural gains, training parameters, transfer mechanisms, and neural correlates.NPJ digital medicine · 2026Article
- Immersive competence as a source of bias in virtual reality clinical assessment.NPJ digital medicine · 2026Article
- Expressive writing combined with digital cognitive therapy in patients with schizophrenia: a narrative review of efficacy, linguistic phenotypes, and adherence modulators.Frontiers in psychiatry · 2026Review
- Adaptive visuospatial n-back training improves audiovisual integration and executive control in older adults.Frontiers in psychology · 2026Article
- From Social Robotics to Ecological Cognitive Care: An Enaction-Based Umbrella Review on Neurocognitive Disorders.Healthcare (Basel, Switzerland) · 2025Review
- Twenty minutes of Corsi block tapping task training does not improve mental rotation in adults with stroke.Frontiers in neurology · 2025Article
- The Effect of the Mediterranean Diet-Integrated Gamified Home-Based Cognitive-Nutritional (GAHOCON) Training Programme for Older People With Cognitive Frailty: Pilot Randomized Controlled Trial.JMIR rehabilitation and assistive technologies · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although computerized cognitive training (CCT) is an effective digital intervention for cognitive impairment, its dose-response relationship is understudied. This retrospective cohort study explores the association between training dose and cognitive improvement to find the optimal CCT dose. From 2017 to 2022, 8,709 participants with subjective cognitive decline, mild cognitive impairment, and mild dementia were analyzed. CCT exposure varied in daily dose and frequency, with cognitive improvement measured weekly using Cognitive Index. A mixed-effects model revealed significant Cognitive Index increases across most dose groups before reaching the optimal dose. For participants under 60 years, the optimal dose was 25 to <30 min per day for 6 days a week. For those 60 years or older, it was 50 to <55 min per day for 6 days a week. These findings highlight a dose-dependent effect in CCT, suggesting age-specific optimal dosing for cognitive improvement.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.