Evidence map›Paper›PMID 39147718›Full record

ArticleZoological research2024

PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm quality.

Chun-Xue Niu, Jia-Wei Li, Xiao-Li Li, Lin-Lin Zhang, Yan Lang, Zhen-Bo Song, Chun-Lei Yu, Xiao-Guang Yang, Hai-Feng Zhao, Jia-Ling Sun and 6 more

Abstract read
In one paragraph

Article in Zoological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. PathogenicCurrent issues in molecular biology · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chun-Xue NiuNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, Jilin 130117, China.
Jia-Wei LiNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, Jilin 130117, China.
Xiao-Li LiChina International Joint Research Center for Human Stem Cell Bank, Northeast Normal University, Changchun, Jilin 130117, China.
Lin-Lin ZhangNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, Jilin 130117, China.
Yan LangChina International Joint Research Center for Human Stem Cell Bank, Northeast Normal University, Changchun, Jilin 130117, China.
Zhen-Bo SongChina International Joint Research Center for Human Stem Cell Bank, Northeast Normal University, Changchun, Jilin 130117, China. E-mail: songzb484@nenu.edu.cn.
Chun-Lei YuChina International Joint Research Center for Human Stem Cell Bank, Northeast Normal University, Changchun, Jilin 130117, China.
Xiao-Guang YangChina International Joint Research Center for Human Stem Cell Bank, Northeast Normal University, Changchun, Jilin 130117, China.
Hai-Feng ZhaoJilin Institute for Drug Control, Changchun, Jilin 130022, China.
Jia-Ling SunJilin Institute for Drug Control, Changchun, Jilin 130022, China.
Li-Hua ZhengChina International Joint Research Center for Human Stem Cell Bank, Northeast Normal University, Changchun, Jilin 130117, China.
Xue WangJilin Institute for Drug Control, Changchun, Jilin 130022, China.
Ying SunChina International Joint Research Center for Human Stem Cell Bank, Northeast Normal University, Changchun, Jilin 130117, China.
Xiao-Hong HanJilin Institute for Drug Control, Changchun, Jilin 130022, China.
Guan-Nan WangChina International Joint Research Center for Human Stem Cell Bank, Northeast Normal University, Changchun, Jilin 130117, China.
Yong-Li BaoNational Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, Jilin 130117, China. E-mail: baoyl800@nenu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serine protease 50 (PRSS50/TSP50) is highly expressed in spermatocytes. Our study investigated its role in testicular development and spermatogenesis. Initially, PRSS50 knockdown was observed to impair DNA synthesis in spermatocytes. To further explore this, we generated PRSS50 knockout (

Indexed as

MAP Kinase Signaling SystemMeiosisMice, KnockoutSpermatozoaAnimalsDual Specificity Phosphatase 6MaleMiceSerine EndopeptidasesSpermatogenesisTestisDual Specificity Phosphatase 6Serine EndopeptidasesERKMeiotic progressionMKP3PRSS50 (TSP50)Sperm quality

Identifiers

PMID39147718
PMCPMC11491780

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.