Evidence map›Paper›PMID 39147608›Full record

ArticleJournal of pediatric urology2024

Identification of urological anomalies associated with anorectal malformation in southwestern Uganda: Limitations and opportunities.

Felix Oyania, Nnaemeka Eze, Mercy Aturinde, Sarah Ullrich, Marvin Mwesigwa, Doruk E Ozgediz

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Article in Journal of pediatric urology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Felix OyaniaMbarara University of Science and Technology, Uganda. Electronic address: oyafel@icloud.com.
Nnaemeka EzeDuke University Medical Center, Uganda. Electronic address: anthony.eze@duke.edu.
Mercy AturindeMbarara University of Science and Technology, Uganda. Electronic address: maturinde74@gmail.com.
Sarah UllrichCincinnati Children's Hospital Medical Center, Uganda. Electronic address: sarahjullrich@gmail.com.
Marvin MwesigwaMbarara University of Science and Technology, Uganda. Electronic address: mmmwesigwa83@gmail.com.
Doruk E OzgedizUniversity of California, San Francisco, Uganda. Electronic address: Doruk.Ozgediz@ucsf.edu.

Funding

University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
FIC NIH HHS D43 TW009343
6 · The paper itself

Abstract

introductionAnorectal malformations (ARMs) may be associated with congenital anomalies affecting other body parts namely vertebral, anorectal, cardiac, tracheoesophageal, renal, and limb (VACTERL) with varying incidences of 7%-60% . Genitourinary defects might occur approximately in 50% of all patients with anorectal malformations hence patients should be evaluated from birth to rule out these defects.

objectiveTo identify urological anomalies associated with anorectal malformation in southwestern Uganda. STUDY

designThis was a descriptive retrospective cohort study conducted at our regional referral hospital in Southwestern Uganda involving patients who have undergone surgical correction of ARMs between June 2021 and July 2023.

resultsThe overall prevalence of renal anomalies in our study patient population was 18.05%. Of those with ARM-associated renal anomalies, Specific anomalies included; renal agenesis (6.8%), hydronephrosis, (4.5%), duplex collecting system (3.8%), crossed fused kidney (1.5%), and ectopic kidney (0.75%). (Table) DISCUSSION: We found that the prevalence of ARM-associated renal anomalies was 18.05%, and the commonest anomaly was unilateral agenesis (6.8%) similar to other studies. Previous data have shown renal anomalies are common anomalies in ARM. While the exact values vary across studies, they all concluded that the rate of associated anomalies is extremely high in ARMs and warrants a thorough preoperative investigation once the ARMs are detected. This finding therefore underscores the importance of thorough evaluation and a multidisciplinary approach of care and follow-up system for ARM management including urologists even when the children are asymptomatic now. The main limitation of our study was missing information on patients' charts, we were not able to get the diagnosis since most patients didn't have their discharge forms at the time of evaluation.

conclusionARM associated with renal anomalies may remain undiagnosed and asymptomatic. Those identified as asymptomatic need to be followed in a multidisciplinary fashion including pediatric urologists.

Indexed as

Anorectal malformationCongenitalRenal anomaliesSouthwestern Uganda

Identifiers

PMID39147608
PMCPMC11802888

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