Evidence map›Paper›PMID 39147294›Full record

Trial reportNeuroImage2024

tDCS-enhanced cognitive training improves attention and alters connectivity in control and somatomotor networks: A triple blind study.

Rebecca Kazinka, Donovan Roediger, Lei Xuan, Lingyan Yu, Bryon A Mueller, Jazmin Camchong, Alexander Opitz, Angus MacDonald, Kelvin O Lim

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in NeuroImage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rebecca KazinkaUniversity of Minnesota, Department of Psychiatry and Behavioral Sciences, United States; University of Minnesota, Department of Biomedical Engineering, United States.
Donovan RoedigerUniversity of Minnesota, Department of Psychiatry and Behavioral Sciences, United States.
Lei XuanUniversity of Minnesota, Department of Psychiatry and Behavioral Sciences, United States.
Lingyan YuUniversity of Minnesota, Department of Psychology, United States.
Bryon A MuellerUniversity of Minnesota, Department of Psychiatry and Behavioral Sciences, United States.
Jazmin CamchongUniversity of Minnesota, Department of Psychiatry and Behavioral Sciences, United States.
Alexander OpitzUniversity of Minnesota, Department of Biomedical Engineering, United States.
Angus MacDonaldUniversity of Minnesota, Department of Psychology, United States.
Kelvin O LimUniversity of Minnesota, Department of Psychiatry and Behavioral Sciences, United States.

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger, KAMIL UGURBIL · 2019 to 2026
$11.7M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Increased thalamocortical connectivity in tdcs-potentiated generalization of cognitive trainingRF1MH116987 · NIMH · UNIVERSITY OF MINNESOTA · PI LIM, KELVIN O., MACDONALD, ANGUS W · 2018 to 2018
$2.8M
Using Computation to Achieve Breakthroughs in NeuroscienceT32MH115886 · NIMH · UNIVERSITY OF MINNESOTA · PI REDISH, A DAVID · 2018 to 2022
$1.7M
Minnesota Neuroimaging Postdoctoral Training GrantT32EB031512 · NIBIB · UNIVERSITY OF MINNESOTA · PI NETOFF, THEODEN I, UGURBIL, KAMIL · 2021 to 2025
$1.1M
High Performance Connectome Upgrade for Human 3T MR ScannerS10OD017974 · OD · UNIVERSITY OF MINNESOTA · PI LIM, KELVIN O. · 2014 to 2014
$600k
NIBIB NIH HHS P41 EB027061NIBIB NIH HHS T32 EB031512NIH HHS S10 OD017974NIMH NIH HHS RF1 MH116987NIMH NIH HHS T32 MH115886NINDS NIH HHS P30 NS076408
6 · The paper itself

Abstract

backgroundExecutive dysfunction such as inattention or forgetfulness can lead to disruptions in a person's daily functioning and quality of life. OBJECTIVE/HYPOTHESIS: This triple-blinded randomized clinical trial assessed the efficacy of bifrontal (over the forehead) transcranial direct current stimulation (tDCS) concurrent with cognitive training to improve cognitive performance in a healthy sample.

methodsFifty-eight participants were randomly assigned to one of three stimulation conditions (2 mA left anode-right cathode, 2 mA right anode-left cathode, or sham), which was administered with cognitive training tasks 3x/week over 12 weeks with assessments at baseline, midpoint (6 weeks), and post-training (12 weeks). We assessed cognitive performance, functional connectivity, and the influence of individual differences in training advancement.

resultsForty participants completed training. We found that at midpoint and post, all groups improved significantly on overall cognitive performance. The left anode group's attention & vigilance score improved significantly at post, but the other two groups did not. Greater attention training advancement predicted attention improvement by post, most notably in the left anode group. Finally, within-network connectivity decreased in the control network and increased in the somatomotor network across all groups.

conclusionsThese results suggest that, given cognitive training, the left anode montage is more effective at improving attention than the right anode montage and sham. Future research may focus on the application of the left anode montage during cognitive training to assess its effectiveness in improving cognition in neuropsychiatric disorders.

Indexed as

AttentionTranscranial Direct Current StimulationAdultCognitionCognitive TrainingExecutive FunctionFemaleHumansMagnetic Resonance ImagingMaleNerve NetYoung AdultAttentionCognitionfMRINon-invasive brain stimulationTranscranial direct current stimulation

Identifiers

PMID39147294
PMCPMC11425656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.