Evidence map›Paper›PMID 39146801›Full record

Trial reportCell host & microbe2024

Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome.

Trishla Sinha, Jelmer R Prins, Asier Fernández-Pato, Marloes Kruk, Thomas Dierikx, Tim de Meij, Marjon de Boer, Jan Freark de Boer, Sicco Scherjon, Alexander Kurilshikov and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell host & microbe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06030713 (Timing of Umbilical Cord Clamping During an Elective Caesarean Delivery and Its Association With Neonatal Gut Microbiome.), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06030713 nacompletednot on this map

Timing of Umbilical Cord Clamping During an Elective Caesarean Delivery and Its Association With Neonatal Gut Microbiome.

TypeinterventionalSponsorUniversity Medical Center GroningenRan2019 to 2023Enrolled33ConditionsMicrobial Colonization, Antibiotic Side Effect, Cesarean Section ComplicationsArmsCefazolin
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
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  6. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Trishla SinhaDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address: t.sinha@rug.nl.
Jelmer R PrinsDepartment of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Asier Fernández-PatoDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Marloes KrukDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Thomas DierikxDepartment of Medical Microbiology, Maastricht University Medical Center, Maastricht, the Netherlands.
Tim de MeijDepartment of Paediatric Gastroenterology, Amsterdam UMC, Emma Children's Hospital, Amsterdam, the Netherlands.
Marjon de BoerDepartment of Obstetrics and Gynaecology, Reproduction and Development, Amsterdam UMC Locatie VUmc, Amsterdam, the Netherlands.
Jan Freark de BoerDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Sicco ScherjonDepartment of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Alexander KurilshikovDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Alexandra ZhernakovaDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnant women undergoing a cesarean section (CS) typically receive antibiotics prior to skin incision to prevent infections. To investigate if the timing of antibiotics influences the infant gut microbiome, we conducted a randomized controlled trial (NCT06030713) in women delivering via a scheduled CS who received antibiotics either before skin incision or after umbilical cord clamping. We performed a longitudinal analysis on 172 samples from 28 infants at 8 post-birth time points and a cross-sectional analysis at 1 month in 79 infants from 3 cohorts. Although no significant associations with bacterial composition, metabolic pathways, short-chain fatty acids, and bile acids were found, we observed subtle differences between the groups at the bacterial strain level and in the load of antibiotic resistance genes. Rather, feeding mode was a predominant and defining factor impacting infant microbial composition. In conclusion, antibiotic administration during CS has only limited effects on the early-life gut microbiome.

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisCesarean SectionGastrointestinal MicrobiomeAdultBacteriaBile Acids and SaltsCross-Sectional StudiesFecesFemaleHumansInfantInfant, NewbornLongitudinal StudiesMalePregnancyAnti-Bacterial AgentsBile Acids and Saltsantibiotic resistance genescesarean sectionfeeding modeinfant gut microbiomematernal prophylactic antibioticsresistomestrain variability

Identifiers

PMID39146801
PMCPMC11335186

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.