Evidence map›Paper›PMID 39146669›Full record

ArticleESMO open2024

Performances of preoperative CT scan to predict the pTN stage for MSI/dMMR localized colon cancers.

M Duval, Q Vanderbecq, V Phou, B Cervantes, L Mas, J-B Bachet, C Goumard, Y Parc, T André, J H Lefèvre and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in ESMO open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

M DuvalSorbonne Université, Service d'Oncologie Médicale, Hôpital Saint Antoine, AP-HP, INSERM UMRS 938, Centre de Recherche Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, SIRIC CURAMUS, Paris. Electronic address: martin.duval@aphp.fr.
Q VanderbecqSorbonne Université, Service de Radiologie, Hôpital Saint Antoine, APHP, Laboratoire d'Imagerie Biomédicale, UMR 7371, UMR S 1146, Paris.
V PhouSorbonne Université, Service d'Imagerie (SISU), Hôpital Pitié Salpêtrière, APHP, Laboratoire d'Imagerie Biomédicale, UMR 7371, UMR_S 1146, Paris.
B CervantesSorbonne Université, Service d'Oncologie Médicale, Hôpital Saint Antoine, AP-HP, INSERM UMRS 938, Centre de Recherche Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, SIRIC CURAMUS, Paris.
L MasSorbonne Université, Service d'Hépato-gastroentérologie et Oncologie Digestive, Hôpital Pitié Salpêtrière, APHP, Paris.
J-B BachetSorbonne Université, Service d'Hépato-gastroentérologie et Oncologie Digestive, Hôpital Pitié Salpêtrière, APHP, Paris.
C GoumardSorbonne Université, Service de Chirurgie Digestive, Hépatobiliaire et Transplantation Hépatique, Hôpital Pitié Salpêtrière, Centre de Recherche Saint-Antoine, INSERM UMR S-938, Paris.
Y ParcSorbonne Université, Service de Chirurgie Générale et Digestive, Hôpital Saint-Antoine, AP-HP, INSERM UMRS 938, Centre de Recherche Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, SIRIC CURAMUS, Paris, France.
T AndréSorbonne Université, Service d'Oncologie Médicale, Hôpital Saint Antoine, AP-HP, INSERM UMRS 938, Centre de Recherche Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, SIRIC CURAMUS, Paris.
J H LefèvreSorbonne Université, Service de Chirurgie Générale et Digestive, Hôpital Saint-Antoine, AP-HP, INSERM UMRS 938, Centre de Recherche Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, SIRIC CURAMUS, Paris, France.
O LucidarmeSorbonne Université, Service d'Imagerie (SISU), Hôpital Pitié Salpêtrière, APHP, Laboratoire d'Imagerie Biomédicale, UMR 7371, UMR_S 1146, Paris.
L ArrivéSorbonne Université, Service de Radiologie, Hôpital Saint Antoine, APHP, Laboratoire d'Imagerie Biomédicale, UMR 7371, UMR S 1146, Paris.
R CohenSorbonne Université, Service d'Oncologie Médicale, Hôpital Saint Antoine, AP-HP, INSERM UMRS 938, Centre de Recherche Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, SIRIC CURAMUS, Paris.
M WagnerSorbonne Université, Service d'Imagerie (SISU), Hôpital Pitié Salpêtrière, APHP, Laboratoire d'Imagerie Biomédicale, UMR 7371, UMR_S 1146, Paris.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeoadjuvant immunotherapy emerges as a promising strategy for patients with localized colon cancer (CC) harboring microsatellite instability/mismatch repair deficiency (MSI/dMMR). The aim of this study is to evaluate the concordance between clinical cTN stage assessed by preoperative computed tomography (CT) scan and pTN stage of MSI/dMMR CC. PATIENTS AND

methodsConsecutive patients diagnosed for localized MSI/dMMR CC and treated with upfront surgery between 2013 and 2022 in two French centers were eligible. Two independent radiologists, blinded to pathological findings, reviewed all preoperative CT scans and assessed cTN stage, with a third radiologist reviewing discordant cases. Radiological predictive diagnostic accuracy for pT4 and pN+ (N+ = N1 or N2) were calculated.

resultsOne hundred and thirteen patients were included (right CCs = 79%). CT scan diagnostic performances for pT4 were sensitivity (Se) = 33.3%; specificity (Sp) = 94.0%; positive predictive value (PPV) = 66.7%; and negative predictive value (NPV) = 79.6% and for pN+ were Se = 70.3%; Sp = 59.2%; PPV = 45.6%; and NPV = 80.4%. When pT-pN were combined, 37.5% of tumors identified as cT4 and/or cN+ were actually pT1-3 and pN0, and 23.1% of the pT4 and pN+ population was not identified as such radiologically.

conclusionThe ability of preoperative CT scan to predict pT and pN stages is limited for localized MSI/dMMR CCs. Reassessing neoadjuvant strategies' benefit-risk balance in this population is needed.

Indexed as

Colonic NeoplasmsMicrosatellite InstabilityNeoplasm StagingTomography, X-Ray ComputedAdultAgedDNA Mismatch RepairFemaleHumansMaleMiddle AgedNeoadjuvant TherapyPredictive Value of TestsPreoperative CareRetrospective Studiescolon cancerimmune checkpoint inhibitorMSI/dMMRneoadjuvant therapypreoperative staging

Identifiers

PMID39146669
PMCPMC11374966

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.