Evidence map›Paper›PMID 39146526›Full record

Trial reportThe Journal of urology2024

Randomized Controlled Trial of Ultrasonic Propulsion-Facilitated Clearance of Residual Kidney Stone Fragments vs Observation.

Mathew D Sorensen, Barbrina Dunmire, Jeff Thiel, Bryan W Cunitz, Barbara H Burke, Branda J Levchak, Christina Popchoi, Arturo E Holmes, John C Kucewicz, M Kennedy Hall and 7 more

2 registry-linked trialsAbstract readRandomized Controlled TrialMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of urology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02028559 naactive not recruitingnot on this map

Safety and Effectiveness of the Ultrasonic Propulsion of Kidney Stones

TypeinterventionalSponsorUniversity of WashingtonRan2013 to 2026Enrolled172ConditionsKidney Stones, Nephrolithiasis, UrolithiasisArmsPropulse 1 with C5-2 probe, Propulse 1 with SC-X probe
NCT04796792 narecruitingnot on this map

Ultrasound Technology to Fragment and Reposition Urinary Stones

TypeinterventionalSponsorUniversity of WashingtonRan2023 to 2028Enrolled140ConditionsUrinary Stone, Urinary CalculiArmsBurst Wave Lithotripsy (BWL) and Ultrasonic Propulsion (UP)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Mathew D SorensenDepartment of Urology, University of Washington School of Medicine, Seattle, Washington.
Barbrina DunmireCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington.
Jeff ThielCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington.
Bryan W CunitzCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington.
Barbara H BurkeInstitute of Translational Health Sciences, University of Washington, Seattle, Washington.
Branda J LevchakSeattle Institute for Biomedical and Clinical Research, Veterans Affairs Puget Sound Health Care System, Seattle, Washington.
Christina PopchoiCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington.
Arturo E HolmesDepartment of Urology, University of Washington School of Medicine, Seattle, Washington.
John C KucewiczCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington.
M Kennedy HallDepartment of Emergency Medicine, University of Washington School of Medicine, Seattle, Washington.
Manjiri DigheDepartment of Radiology, University of Washington School of Medicine, Seattle, Washington.
Jessica C DaiEvergreenHealth Urology Care, Kirkland, Washington.
Fionnuala C CormackDivision of Nephrology, Department of Medicine, University of Washington, Seattle, Washington.
Ziyue LiuDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana.
Michael R BaileyDepartment of Urology, University of Washington School of Medicine, Seattle, Washington.ORCID 0000-0003-0491-6465
Michael P PorterDepartment of Urology, University of Washington School of Medicine, Seattle, Washington.
Jonathan D HarperDepartment of Urology, University of Washington School of Medicine, Seattle, Washington.

Funding

SWL AND RENAL INJURY AND STONE COMMINUTIONP01DK043881 · NIDDK · UNIVERSITY OF WASHINGTON · PI BAILEY, MICHAEL R · 1994 to 2023
$33.5M
NIDDK NIH HHS P01 DK043881
6 · The paper itself

Abstract

purposeUltrasonic propulsion is an investigational procedure for awake patients. Our purpose was to evaluate whether ultrasonic propulsion to facilitate residual kidney stone fragment clearance reduced relapse. MATERIALS AND

methodsThis multicenter, prospective, open-label, randomized, controlled trial used single block randomization (1:1) without masking. Adults with residual fragments (individually ≤5 mm) were enrolled. Primary outcome was relapse as measured by stone growth, a stone-related urgent medical visit, or surgery by 5 years or study end. Secondary outcomes were fragment passage within 3 weeks and adverse events within 90 days. Cumulative incidence of relapse was estimated using the Kaplan-Meier method. Log-rank test was used to compare the treatment (ultrasonic propulsion) and control (observation) groups.

resultsThe trial was conducted from May 9, 2015, through April 6, 2024. Median follow-up (interquartile range) was 3.0 (1.8-3.2) years. The treatment group (n = 40) had longer time to relapse than the control group (n = 42;

conclusionsUltrasonic propulsion reduced relapse and added minimal risk.

Indexed as

Kidney CalculiRecurrenceAdultAgedFemaleHumansLithotripsyMaleMiddle AgedProspective StudiesTreatment OutcomeUltrasonic TherapyWatchful Waitingkidney stoneslithotripsyultrasound

Identifiers

PMID39146526
PMCPMC11560600

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.