Evidence map›Paper›PMID 39145995›Full record

ArticleChemMedChem2024

Unraveling the Molecular Reason of Opposing Effects of α-Mangostin and Norfluoxetine on TREK-2 at the Same Binding Site.

Gangrae Kim, Nhung Thi Hong Van, Joo Hyun Nam, Wook Lee

Abstract read
In one paragraph

Article in ChemMedChem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gangrae KimDepartment of Biochemistry, Kangwon National University, College of Natural Sciences, Chuncheon, 24341, Republic of Korea.
Nhung Thi Hong VanDepartment of Physiology, Dongguk University, College of Medicine, Gyeongju, 38066, Republic of Korea.
Joo Hyun NamDepartment of Physiology, Dongguk University, College of Medicine, Gyeongju, 38066, Republic of Korea.
Wook LeeDepartment of Biochemistry, Kangwon National University, College of Natural Sciences, Chuncheon, 24341, Republic of Korea.ORCID 0000-0003-4646-7012

Funding

Kangwon National University 520200114Korea government (MSIT, Ministry of Science and ICT) 2021R1A2C1004344National Research Foundation of Korea (NRF)
6 · The paper itself

Abstract

TWIK-related K

Indexed as

Potassium Channels, Tandem Pore DomainXanthonesAnalgesicsBinding SitesFluoxetineHEK293 CellsHumansMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipAnalgesicsFluoxetineKCNK10 protein, humanmangostinnorfluoxetinePotassium Channels, Tandem Pore DomainXanthonesAlpha-mangostinIon channelModulationMolecular dynamicsTREK-2

Identifiers

PMID39145995
PMCPMC11617644

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.