Evidence map›Paper›PMID 39145930›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Disorder-to-order active site capping regulates the rate-limiting step of the inositol pathway.

Toni K Träger, Fotis L Kyrilis, Farzad Hamdi, Christian Tüting, Marie Alfes, Tommy Hofmann, Carla Schmidt, Panagiotis L Kastritis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Toni K TrägerFaculty of Natural Sciences I, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID 0000-0002-7001-2619
Fotis L KyrilisInstitute of Chemical Biology, National Hellenic Research Foundation, Athens 11635, Greece.ORCID 0000-0002-4040-6289
Farzad HamdiFaculty of Natural Sciences I, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID 0000-0002-2155-5000
Christian TütingFaculty of Natural Sciences I, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID 0000-0001-6209-4012
Marie AlfesInterdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID 0000-0001-5006-9573
Tommy HofmannInterdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID 0000-0002-9646-7136
Carla SchmidtFaculty of Natural Sciences I, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID 0000-0001-9410-1424
Panagiotis L KastritisFaculty of Natural Sciences I, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID 0000-0002-1463-8422

Funding

Bundesministerium für Bildung und Forschung (BMBF) 03COV04Bundesministerium für Bildung und Forschung (BMBF) 03Z22HI2Bundesministerium für Bildung und Forschung (BMBF) 03Z22HN22Bundesministerium für Bildung und Forschung (BMBF) 03Z22HN23Deutsche Forschungsgemeinschaft (DFG) 391498659EC | Horizon Europe | WPSERA | HORIZON EUROPE Widening participation and spreading excellence (WPSE) 101086665
6 · The paper itself

Abstract

Myo-inositol-1-phosphate synthase (MIPS) catalyzes the NAD

Indexed as

Catalytic DomainInositolMyo-Inositol-1-Phosphate SynthaseFungal ProteinsGlucose-6-PhosphateInositol PhosphatesModels, MolecularProtein ConformationFungal ProteinsGlucose-6-PhosphateInositolinositol 1-phosphateInositol PhosphatesMyo-Inositol-1-Phosphate Synthaseconformational selectioncryo-EMendogenousinduced fitinositol metabolism

Identifiers

PMID39145930
PMCPMC11348189

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.