Evidence map›Paper›PMID 39145469›Full record

ArticleFuture medicinal chemistry2024

Discovery of novel ULK1 inhibitors through machine learning-guided virtual screening and biological evaluation.

Miao-Miao Kong, Tao Wei, Bo Liu, Zi-Xuan Xi, Jun-Tao Ding, Xin Liu, Ke Li, Tian-Li Qin, Zhen-Yong Qian, Wen-Can Wu and 2 more

Abstract read
In one paragraph

Article in Future medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Autophagy modulation in cancer.Nature reviews. Drug discovery · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Miao-Miao KongThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.ORCID 0009-0007-2402-8277
Tao WeiSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Bo LiuFaculty of Applied Sciences, Macao Polytechnic University, Macao, SAR, China.
Zi-Xuan XiThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Jun-Tao DingThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Xin LiuSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Ke LiThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Tian-Li QinThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Zhen-Yong QianThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Wen-Can WuThe Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, 325027, China.
Jian-Zhang WuOujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision & Brain Health), Wenzhou, Zhejiang, 325000, China.
Wu-Lan LiThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.ORCID 0000-0001-9442-1743

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Autophagy-Related Protein-1 HomologDrug DiscoveryMachine LearningMolecular Docking SimulationProtein Kinase InhibitorsDrug Evaluation, PreclinicalHumansIntracellular Signaling Peptides and ProteinsMolecular Dynamics SimulationMolecular StructureAutophagy-Related Protein-1 HomologIntracellular Signaling Peptides and ProteinsProtein Kinase InhibitorsULK1 protein, humandrug discoverymachine learningmolecular dynamics simulationULK1 inhibitorsvirtual screening

Identifiers

PMID39145469
PMCPMC11485869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.