Evidence map›Paper›PMID 39145138›Full record

ArticleBiomedicine hub

Bronchoscopy-Guided High-Power Microwave Ablation in an in vivo Porcine Lung Model.

Jan Sebek, Steven Goh, Warren L Beard, David S Biller, David S Hodgson, Margaret A Highland, Abbe Smith, Nicholas Hemphill, Kun-Chang Yu, Renelle A Myers and 3 more

Abstract read
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In one paragraph

Article in Biomedicine hub. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jan SebekMike Wiegers Department of Electrical and Computer Engineering, Kansas State University, Manhattan, KS, USA.
Steven GohPhenoMapper, LLC, San Jose, CA, USA.
Warren L BeardDepartment of Clinical Sciences, Kansas State University, Manhattan, KS, USA.
David S BillerDepartment of Clinical Sciences, Kansas State University, Manhattan, KS, USA.
David S HodgsonDepartment of Clinical Sciences, Kansas State University, Manhattan, KS, USA.
Margaret A HighlandDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.
Abbe SmithBroncus Medical, Inc., San Jose, CA, USA.
Nicholas HemphillDepartment of Clinical Sciences, Kansas State University, Manhattan, KS, USA.
Kun-Chang YuBroncus Medical, Inc., San Jose, CA, USA.
Renelle A MyersDepartment of Integrative Oncology, British Columbia Cancer Research Center, and The University of British Columbia, Vancouver, BC, Canada.
Stephen LamDepartment of Integrative Oncology, British Columbia Cancer Research Center, and The University of British Columbia, Vancouver, BC, Canada.
Henky WibowoPhenoMapper, LLC, San Jose, CA, USA.
Punit PrakashMike Wiegers Department of Electrical and Computer Engineering, Kansas State University, Manhattan, KS, USA.

Funding

Bronchoscope-guided microwave ablation of early-stage lung tumorsR01CA218357 · NCI · KANSAS STATE UNIVERSITY · PI PRAKASH, PUNIT · 2018 to 2022
$1.3M
NCI NIH HHS R01 CA218357
6 · The paper itself

Abstract

Introduction: Percutaneous microwave ablation (MWA) is clinically accepted for the treatment of lung tumors and oligometastatic disease. Bronchoscopic MWA is under development and evaluation in the clinical setting. We previously reported on the development of a bronchoscopy-guided MWA system integrated with clinical virtual bronchoscopy and navigation and demonstrated the feasibility of transbronchial MWA, using a maximum power of 60 W at the catheter input. Here, we assessed the performance of bronchoscopy-guided MWA with an improved catheter (maximum power handling of up to 120 W) in normal porcine lung in vivo (as in the previous study). Methods: A total of 8 bronchoscopy-guided MWA were performed ( Results: Bronchoscopy-guided MWA with applied energy levels of 90 W/5 min and 120 W/10 min yielded ablation zones with short-axis diameters in the range of 20-28 mm (56-116% increase) as compared to ∼13 mm from our previous study (60 W/10 min). Histology of higher-power and previous lower-power ablations was consistent, including a central necrotic zone, a thermal fixation zone with intact tissue architecture, and a hemorrhagic periphery. Catheter positioning and its confirmation via intra-procedural 3D imaging (e.g., cone-beam CT) proved to be critical for ablation consistency. Conclusion: Bronchoscopy-guided MWA with an improved catheter designed for maximum power 120 W yields large ablations in normal porcine lung in vivo.

Indexed as

Lung cancerMicrowave ablationTransbronchial ablationVirtual bronchoscopy

Identifiers

PMID39145138
PMCPMC11324231

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