Evidence map›Paper›PMID 39145117›Full record

ArticleInternational journal of biochemistry & physiology2023

Fibrinogen in Hamster Cauda Sperm.

T Salters, B Sharpe, S S Raychoudhury, S K Nagdas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biochemistry & physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

T SaltersDepartment of Chemistry, Physics & Materials Science, Fayetteville State University, USA.
B SharpeDepartment of Chemistry, Physics & Materials Science, Fayetteville State University, USA.
S S RaychoudhuryDepartment of Biology, Chemistry and Environmental Health Science, Benedict College, USA.
S K NagdasDepartment of Chemistry, Physics & Materials Science, Fayetteville State University, USA.

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
Function of Epididymis in the Recognition and Elimination of Non-viable SpermatozoaSC3GM125488 · NIGMS · FAYETTEVILLE STATE UNIVERSITY · PI NAGDAS, SUBIR K. · 2018 to 2021
$427k
NIGMS NIH HHS P20 GM103499NIGMS NIH HHS SC3 GM125488
6 · The paper itself

Abstract

Epididymis plays a vital role in promoting sperm maturation and maintaining sperm viability. It has been shown the presence of nonviable sperm in cauda epididymis. We previously identified a secretory protein (260/280KDa oligomers) of hamster cauda epididymal principal cells that binds to nonviable sperm. The 260/280KDa oligomers are composed of 64kDa FGL2 (fibrinogen-like protein-2) and 33kDa FGL1) (fibrinogen-like protein-1). In addition, we have demonstrated that FGL2 is a phospholipid-activated serine protease; the conversion of prothrombin to thrombin by FGL2 followed by the conversion of soluble fibrinogen to insoluble fibrin polymers by thrombin. In the present study, we have shown the presence of a 56kDa fibrinogen β in hamster cauda sperm. The potential role of fibrinogen in hamster physiology is being discussed.

Indexed as

Cauda EpididymisFibrinFibrinogenFibrinogen like Protein2Hamster Sperm

Identifiers

PMID39145117
PMCPMC11323058

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.