Evidence map›Paper›PMID 39145115›Full record

ArticleJournal of the Endocrine Society2024

Identification of Succinate Dehydrogenase Gene Variant Carriers by Blood Biomarkers.

Marcel Gebhardt, Carola Kunath, Dennis Fröbel, Alexander M Funk, Mirko Peitzsch, Svenja Nölting, Timo Deutschbein, Andrzej Januszewicz, Henri J L M Timmers, Mercedes Robledo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marcel GebhardtInstitute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.ORCID https://orcid.org/0009-0006-0278-7953
Carola KunathDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Dennis FröbelInstitute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Alexander M FunkInstitute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Mirko PeitzschInstitute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Svenja NöltingMedizinische Klinik and Poliklinik IV, Ludwig-Maximilians-Universität München, D-80336 Munich, Germany.
Timo DeutschbeinDepartment of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, 97080 Würzburg, Germany.
Andrzej JanuszewiczDepartment of Hypertension, National Institute of Cardiology, 04-628 Warsaw, Poland.
Henri J L M TimmersDepartment of Internal Medicine, Radboud University Medical Centre, 6265 Nijmegen, The Netherlands.
Mercedes RobledoHereditary Endocrine Cancer Group, CNIO, 28029 Madrid, Spain.ORCID https://orcid.org/0000-0001-6256-5902
Arne JahnInstitute for Clinical Genetics, University Hospital Carl Gustav Carus at TUD Dresden University of Technology and Faculty of Medicine of TUD Dresden University of Technology, 01307 Dresden, Germany.
Georgiana ConstantinescuDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Graeme EisenhoferDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.ORCID https://orcid.org/0000-0002-8601-9903
Christina PamporakiDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Susan RichterInstitute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.ORCID https://orcid.org/0000-0002-3549-2477

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Carriers of germline pathogenic variants (PVs) in succinate dehydrogenase genes ( Methods: Blood plasma, urine, peripheral blood mononuclear cells, and erythrocytes from patients with and without Results: Plasma succinate to fumarate ratios effectively distinguished tumor-bearing and asymptomatic patients with and without Conclusion: Blood biomarkers have been underutilized for identifying carriers of

Indexed as

blood plasmaerythrocytesmetabolismPBMCsuccinate dehydrogenase gene variantsurine

Identifiers

PMID39145115
PMCPMC11323779

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.