Evidence map›Paper›PMID 39144992›Full record

ArticleHeliyon2024

Cellular Griffiths-like phase.

Lucas Squillante, Isys F Mello, Luciano S Ricco, Marcos F Minicucci, Aniekan Magnus Ukpong, Antonio C Seridonio, Roberto E Lagos-Monaco, Mariano de Souza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lucas SquillanteSão Paulo State University (Unesp), IGCE - Physics Department, Rio Claro - SP, Brazil.
Isys F MelloSão Paulo State University (Unesp), IGCE - Physics Department, Rio Claro - SP, Brazil.
Luciano S RiccoScience Institute, University of Iceland, Dunhagi-3, IS-107, Reykjavik, Iceland.
Marcos F MinicucciDepartment of Internal Medicine, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
Aniekan Magnus UkpongTheoretical and Computational Condensed Matter and Materials Physics Group, School of Chemistry and Physics, University of KwaZulu-Natal, Pietermaritzburg, South Africa.
Antonio C SeridonioSão Paulo State University (Unesp), Department of Physics and Chemistry, Ilha Solteira - SP, Brazil.
Roberto E Lagos-MonacoSão Paulo State University (Unesp), IGCE - Physics Department, Rio Claro - SP, Brazil.
Mariano de SouzaSão Paulo State University (Unesp), IGCE - Physics Department, Rio Claro - SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein compartmentalization in the frame of a liquid-liquid phase separation is a key mechanism to optimize spatiotemporal control of biological systems. Such a compartmentalization process reduces the intrinsic noise in protein concentration due to stochasticity in gene expression. Employing Flory-Huggins solution theory, Avramov/Casalini's model, and the Grüneisen parameter, we unprecedentedly propose a cellular Griffiths-like phase (CGLP), which can impact its functionality and self-organization. The here-proposed CGLP is key ranging from the understanding of primary organisms' evolution to the treatment of diseases. Our findings pave the way for an alternative Biophysics approach to investigate coacervation processes.

Indexed as

Cell criticalityFlory-Huggins solution theoryGriffiths phaseGrüneisen parameterPrimary organismsProtein compartmentalization

Identifiers

PMID39144992
PMCPMC11320126

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.