Evidence map›Paper›PMID 39144888›Full record

ArticleCureus2024

Delphi Consensus Statement on the Role of Probiotics in the Treatment of Atopic Dermatitis.

Jayakar Thomas, Maleeka Sachdeva, Sandipan Dhar, Anil Ganjoo, Bela Shah, Deepika Pandhi, Koushik Lahiri, Rashmi Agarwal, Soumya Jagadeesan, Pradeep Mane and 2 more

Abstract read
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jayakar ThomasDermatology, Jayakar Thomas Skin Care Centre, Chennai, IND.
Maleeka SachdevaDermatology, Sachdev Clinics, Chandigarh, IND.
Sandipan DharDermatology, The Skin Clinic, Kolkata, IND.
Anil GanjooDermatology, Skinnovation Clinics, New Delhi, IND.
Bela ShahDermatology, Byramjee Jeejeebhoy Medical College, Ahmedabad, Ahmedabad, IND.
Deepika PandhiDermatology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, IND.
Koushik LahiriDermatology, Apollo Gleneagles Hospital, Kolkata, IND.
Rashmi AgarwalDermatology, Meenakshi Cosmoderma Care, Bengaluru, IND.
Soumya JagadeesanDermatology, Amrita Institute of Medical Sciences and Research Center, Ernakulam, IND.
Pradeep ManeMedical Strategic Affairs, Torrent Pharmaceuticals Ltd., Ahmedabad, IND.
Rathish NairMedical Strategic Affairs, Torrent Pharmaceuticals Ltd., Ahmedabad, IND.
Krishnaprasad R KorukondaMedical Strategic Affairs, Torrent Pharmaceuticals Ltd., Ahmedabad, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intense itching and recurrent eczematous lesions. Important factors in the etiopathogenesis of AD include genetic predisposition, epidermal barrier dysfunction, immune dysregulation, and gut and skin dysbiosis. Probiotics could be a potential preventive strategy for allergies including AD through immune system modulation as well as enhancement of the epithelial barrier integrity. To further understand the role of probiotics in the management of AD, a Knowledge, Attitude, and Practices (KAP) survey was conducted. Materials and methods A steering committee comprising nine experts formulated consensus recommendations on the role of probiotics in the management of AD and associated flare-ups through the use of the Knowledge, Attitude, and Practices questionnaire while analyzing literature reviews and responses from a national panel consisting of 175 members. The evidence strength and quality were evaluated based on the Agency for Healthcare Research and Quality (AHRQ) criteria. The acceptance of expert opinions as recommendations was considered upon receiving an endorsement from ≥70% of the panelists, as indicated by a Likert scale. Results The national panel emphasized that the improvement in nutritional status, immunomodulatory properties, and beneficial effects on the gastrointestinal (GI) tract and skin support the use of probiotics in AD. The panel agreed that probiotics should be a part of the complementary therapy in the management of AD and associated flare-ups. Mostly, a probiotics supplementation duration of eight to 12 weeks is preferred by dermatologists. Probiotics, when used as an adjuvant therapy, may serve as a strategy to reduce steroid usage or maintenance therapy in high-risk cases with flares. Conclusion A Delphi-mediated KAP response provides a real-life approach to the use of probiotics in the management of AD. It suggests that probiotics could be useful as an adjuvant therapy in the management of AD and associated flare-ups when used along with traditional treatment.

Indexed as

atopic dermatitisimmunomodulationlactobacillus rhamnosus ggprobioticth1th2treg cells

Identifiers

PMID39144888
PMCPMC11324002

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.