Evidence map›Paper›PMID 39144772›Full record

ArticleSchizophrenia bulletin open2022

Distress Related to Attenuated Psychotic Symptoms: Static and Dynamic Association With Transition to Psychosis, Nonremission, and Transdiagnostic Symptomatology in Clinical High-Risk Patients in an International Intervention Trial.

Barnaby Nelson, Hok Pan Yuen, G Paul Amminger, Gregor Berger, Eric Y H Chen, Lieuwe de Haan, Jessica A Hartmann, Ian B Hickie, Suzie Lavoie, Connie Markulev and 13 more

Erratum issuedAbstract read
In one paragraph

Article in Schizophrenia bulletin open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  4. Trajectories of psychotic-like experiences in youth and associations with lifestyle factors.Journal of child psychology and psychiatry, and allied disciplines · 2026
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  5. Article
  6. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Barnaby NelsonOrygen, Melbourne, Victoria, Australia.
Hok Pan YuenOrygen, Melbourne, Victoria, Australia.
G Paul AmmingerOrygen, Melbourne, Victoria, Australia.
Gregor BergerChild and Adolescent Psychiatric Service of the Canton of Zurich, Zurich, Switzerland.
Eric Y H ChenDepartment of Psychiatry, University of Hong Kong, Hong Kong.
Lieuwe de HaanAcademic Medical Center, Amsterdam, The Netherlands.
Jessica A HartmannOrygen, Melbourne, Victoria, Australia.
Ian B HickieBrain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia.
Suzie LavoieOrygen, Melbourne, Victoria, Australia.
Connie MarkulevOrygen, Melbourne, Victoria, Australia.
Nilufar MossahebDepartment of Psychiatry and Psychotherapy, Clinical Division of Social Psychiatry, Medical University of Vienna, Vienna, Austria.
Dorien H NiemanAcademic Medical Center, Amsterdam, The Netherlands.
Merete NordentoftCORE-Copenhagen Research Centre for Mental Health, Mental Health Centre Copenhagen, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Andrea PolariOrygen, Melbourne, Victoria, Australia.
Anita Riecher-RösslerPsychiatric University Clinics Basel, Basel, Switzerland.
Miriam R SchäferOrygen, Melbourne, Victoria, Australia.
Monika SchlögelhoferDepartment of Child and Adolescent Psychiatry, Medical University Vienna, Vienna, Austria.
Stefan SmesnyUniversity Hospital Jena, Jena, Germany.
Amy TedjaOrygen, Melbourne, Victoria, Australia.
Andrew ThompsonOrygen, Melbourne, Victoria, Australia.
Swapna VermaInstitute of Mental Health, Singapore, Singapore.
Alison R YungOrygen, Melbourne, Victoria, Australia.
Patrick D McGorryOrygen, Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examined whether distress in relation to attenuated psychotic symptoms (DAPS) is associated with clinical outcomes in an ultra-high risk (UHR) for psychosis sample. We also investigated whether DAPS is associated with cognitive style (attributional style and cognitive biases) and whether amount of psychosocial treatment provided is associated with reduction in DAPS. The study was a secondary analysis of the "Neurapro" clinical trial of omega-3 fatty acids. Three hundred and four UHR patients were recruited across 10 early intervention services. Data from baseline assessment, regular assessments over 12 months, and medium term follow-up (mean = 3.4 years) were used for analysis. Findings indicated: a positive association between DAPS assessed over time and transition to psychosis; a significant positive association between baseline and longitudinal DAPS and transdiagnostic clinical and functional outcomes; a significant positive association between baseline and longitudinal DAPS and nonremission of UHR status. There was no relationship between severity of DAPS and cognitive style. A greater amount of psychosocial treatment (cognitive-behavioral case management) was associated with an increase in DAPS scores. The study indicates that UHR patients who are more distressed by their attenuated psychotic symptoms are more likely to have a poorer clinical trajectory transdiagnostically. Assessment of DAPS may therefore function as a useful marker of risk for a range of poor outcomes. The findings underline the value of repeated assessment of variables and incorporation of dynamic change into predictive modeling. More research is required into mechanisms driving distress associated with symptoms and the possible bidirectional relationship between symptom severity and associated distress.

Indexed as

attenuated psychotic symptomscognitive biasessubjective distresstransdiagnosticultra-high risk

Identifiers

PMID39144772
PMCPMC11205873

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.