Evidence map›Paper›PMID 39144728›Full record

ReviewJournal of current glaucoma practice

A Review of Canaloplasty in the Treatment and Management of Glaucoma.

Isabella V Wagner, Caleb Towne, Marie C Saade, P Connor Lentz, Arianna Rashedi, Pranav Vasu, Nithya Boopathiraj, Leticia Checo, Chelsey Krambeer, Darby D Miller and 1 more

Abstract readReview
In one paragraph

Review in Journal of current glaucoma practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Canaloplasty via an ab-interno approach in primary open-angle glaucoma: Results from a large case series.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Isabella V WagnerDepartment of Ophthalmology, Mayo Clinic, Jacksonville, Florida, United States of America.
Caleb TowneDepartment of Ophthalmology, Mayo Clinic, Jacksonville, Florida, United States of America.
Marie C SaadeDepartment of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
P Connor LentzDepartment of Ophthalmology, Mayo Clinic, Jacksonville, Florida, United States of America.
Arianna RashediDepartment of Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, Florida, United States of America.
Pranav VasuDepartment of Medicine, Creighton School of Medicine, Phoenix, Arizona, United States of America.
Nithya BoopathirajDepartment of Ophthalmology, Mayo Clinic, Jacksonville, Florida, United States of America.
Leticia ChecoDepartment of Ophthalmology, Mayo Clinic, Jacksonville, Florida, United States of America.
Chelsey KrambeerDepartment of Ophthalmology, Mayo Clinic, Jacksonville, Florida, United States of America.
Darby D MillerDepartment of Ophthalmology, Mayo Clinic, Jacksonville, Florida, United States of America.
Syril DorairajDepartment of Ophthalmology, Mayo Clinic, Jacksonville, Florida, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: To review the published literature evaluating the safety and efficacy outcomes of canaloplasty performed in the treatment of glaucoma. Background: Canaloplasty is a nonpenetrating glaucoma procedure involving combined 360° circumnavigation and viscodilation of Schlemm's canal. The procedure may be performed under an ab externo (with tensioning suture) or ab-interno (conjunctiva-sparing) approach. Given the wide variety of glaucoma procedure types and approaches, further investigation into the role of canaloplasty in ophthalmological practice is warranted. The objectives of this narrative review are to synthesize the existing literature in order to investigate indications, safety and efficacy outcomes, and the optimal place of canaloplasty in glaucoma treatment and management. Review of results: A total of 60 articles were included in this review. Both ab externo and ab-interno canaloplasty (ABiC) were found to be significantly effective at reducing intraocular pressure (IOP) and glaucoma medication burdens in patients with mild-to-moderate open-angle glaucoma (OAG). These findings remained consistent regardless of phacoemulsification status. ABiC was found to exhibit a safety profile favorable compared to trabeculectomy and comparable to minimally invasive trabecular bypass implants. Conclusion: Canaloplasty is a nonpenetrating surgical intervention that is highly effective in treating patients with mild-to-moderate OAG across a large variety of clinical scenarios. Clinical significance: These findings support the clinical use of canaloplasty in ophthalmological practice, clarify its patient profile, and compare procedural outcomes to other minimally invasive glaucoma surgery (MIGS) devices on the market. How to cite this article: Wagner IV, Towne C, Saade MC,

Indexed as

CanaloplastyGlaucomaGlaucoma surgeryiTrackOMNI surgical system

Identifiers

PMID39144728
PMCPMC11320757

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.