Evidence map›Paper›PMID 39144569›Full record

ArticleACS pharmacology & translational science2024

Small Molecule Inhibitors of Arylamine N-Acetyltransferase 1 Attenuate Cellular Respiration.

Chandra Choudhury, James E Egleton, Neville J Butcher, Angela J Russell, Rodney F Minchin

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chandra ChoudhurySchool of Biomedical Sciences, The University of Queensland, St Lucia, Brisbane, 4069 Queensland Australia.ORCID https://orcid.org/0000-0002-6768-991X
James E EgletonDepartment of Chemistry, University of Oxford, 12A Mansfield Road, Oxford OX1 3TA, U.K.
Neville J ButcherSchool of Biomedical Sciences, The University of Queensland, St Lucia, Brisbane, 4069 Queensland Australia.
Angela J RussellDepartment of Chemistry, University of Oxford, 12A Mansfield Road, Oxford OX1 3TA, U.K.ORCID https://orcid.org/0000-0003-3610-9369
Rodney F MinchinSchool of Biomedical Sciences, The University of Queensland, St Lucia, Brisbane, 4069 Queensland Australia.ORCID https://orcid.org/0000-0002-3178-4835

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arylamine N-acetyltransferase 1 (NAT1) expression has been shown to attenuate mitochondrial function, suggesting it is a promising drug target in diseases of mitochondrial dysfunction. Here, several second-generation naphthoquinones have been investigated as small molecule inhibitors of NAT1. The results show that the compounds inhibit both

Identifiers

PMID39144569
PMCPMC11320739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.