Evidence map›Paper›PMID 39144551›Full record

ArticleACS pharmacology & translational science2024

Radiosynthesis and Evaluation of 11C-Labeled Isoindolone-Based Positive Allosteric Modulators for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor 2.

Yinlong Li, Kenneth Dahl, Peter Johnström, Katarina Varnäs, Lars Farde, Christer Halldin, Amy Medd, Donna Maier, Mark E Powell, Jiahui Chen and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yinlong LiDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
Kenneth DahlPET Science Centre, Precision Medicine and Biosamples, Oncology R&D, AstraZeneca, Karolinska Institutet, Stockholm S-17176, Sweden.
Peter JohnströmPET Science Centre, Precision Medicine and Biosamples, Oncology R&D, AstraZeneca, Karolinska Institutet, Stockholm S-17176, Sweden.
Katarina VarnäsDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm S-17176, Sweden.ORCID https://orcid.org/0000-0001-6167-9254
Lars FardeDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm S-17176, Sweden.
Christer HalldinDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm S-17176, Sweden.
Amy MeddNeuroscience, BioPharmaceuticals R&D, AstraZeneca, Wilmington, Delaware 19803, United States.
Donna MaierNeuroscience, BioPharmaceuticals R&D, AstraZeneca, Wilmington, Delaware 19803, United States.
Mark E PowellNeuroscience, BioPharmaceuticals R&D, AstraZeneca, Wilmington, Delaware 19803, United States.
Jiahui ChenDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0001-9186-1110
Richard VanDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019-5251, United States.
Jimmy PatelDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
Ahmad ChaudharyDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
Yabiao GaoDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
Zhendong SongDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
Achi HaiderDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
Yihan ShaoDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019-5251, United States.ORCID https://orcid.org/0000-0001-9337-341X
Charles S ElmoreNeuroscience, BioPharmaceuticals R&D, AstraZeneca, Wilmington, Delaware 19803, United States.
Steven LiangDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0003-1413-6315
Magnus SchouPET Science Centre, Precision Medicine and Biosamples, Oncology R&D, AstraZeneca, Karolinska Institutet, Stockholm S-17176, Sweden.ORCID https://orcid.org/0000-0002-4314-2418

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The metabotropic glutamate receptor 2 (mGluR

Identifiers

PMID39144551
PMCPMC11320742

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.