ArticleSIAM journal on imaging sciences2023
Toward Single Particle Reconstruction without Particle Picking: Breaking the Detection Limit.
Article in SIAM journal on imaging sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- EXPECTATION-MAXIMIZATION FOR STRUCTURE DETERMINATION DIRECTLY FROM CRYO-EM MICROGRAPHS.Inverse problems and imaging (Springfield, Mo.) · 2027Article
- Subspace Method of Moments forSIAM journal on imaging sciences · 2026Article
- Structure determination using high-order spatial correlations in single-particle X-ray scattering.IUCrJ · 2024Article
- Autocorrelation analysis for cryo-EM with sparsity constraints: Improved sample complexity and projection-based algorithms.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- MULTI-TARGET DETECTION WITH ROTATIONS.Inverse problems and imaging (Springfield, Mo.) · 2023Article
- Super-resolution multi-reference alignment.Information and inference : a journal of the IMA · 2022Article
- An approximate expectation-maximization for two-dimensional multi-target detection.IEEE signal processing letters · 2022Article
- Single-particle cryo-electron microscopy: Mathematical theory, computational challenges, and opportunities.IEEE signal processing magazine · 2020Article
- Multi-target Detection with an Arbitrary Spacing Distribution.IEEE transactions on signal processing : a publication of the IEEE Signal Processing Society · 2020Article
- Multi-target detection with application to cryo-electron microscopy.Inverse problems · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method to resolve biological macromolecules. In a cryo-EM experiment, the microscope produces images called micrographs. Projections of the molecule of interest are embedded in the micrographs at unknown locations, and under unknown viewing directions. Standard imaging techniques first locate these projections (detection) and then reconstruct the 3-D structure from them. Unfortunately, high noise levels hinder detection. When reliable detection is rendered impossible, the standard techniques fail. This is a problem, especially for small molecules. In this paper, we pursue a radically different approach: we contend that the structure could, in principle, be reconstructed directly from the micrographs, without intermediate detection. The aim is to bring small molecules within reach for cryo-EM. To this end, we design an autocorrelation analysis technique that allows one to go directly from the micrographs to the sought structures. This involves only one pass over the micrographs, allowing online, streaming processing for large experiments. We show numerical results and discuss challenges that lay ahead to turn this proof-of-concept into a complementary approach to state-of-the-art algorithms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.