ArticleFrontiers in bioengineering and biotechnology2024
High-throughput detection of potential bacteriocin producers in a large strain library using live fluorescent biosensors.
Article in Frontiers in bioengineering and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Detection and quantification of membrane-damaging antimicrobials using pHluorin2-based bacterial biosensors.Frontiers in microbiology · 2026Article
- Biosensors in Microbial Ecology: Revolutionizing Food Safety and Quality.Microorganisms · 2025Review
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Authors and funding
7 authors.
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Abstract
The global increase in antibiotic resistances demands for additional efforts to identify novel antimicrobials such as bacteriocins. These antimicrobial peptides of bacterial origin are already used widely in food preservation and promising alternatives for antibiotics in animal feed and some clinical setting. Identification of novel antimicrobials is facilitated by appropriate high throughput screening (HTS) methods. Previously, we have described a rapid, simple and cost-efficient assay based on live biosensor bacteria for detection of antimicrobial compounds that act on membrane integrity using the ratiometric pH-dependent fluorescent protein pHluorin2 (pHin2). Here, we use these biosensors to develop an integrated pipeline for high-throughput identification of bacteriocin producers and their biosynthetic gene clusters. We extend the existing portfolio of biosensors by generating pHin2 expressing strains of
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