ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2024
Identification of a Conversion Factor for Dexmedetomidine to Clonidine Transitions.
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Tiny doses, big impact: Optimizing sedation weaning to reduce opioid use in a Level IV NICU.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Enhancing Caudal Analgesia in Children: A Narrative Review of Clonidine and Dexmedetomidine as Adjuvants.Cureus · 2025Review
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2 authors.
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Abstract
objectiveTo determine a conversion factor for use when switching from dexmedetomidine infusion to enteral clonidine in critically ill neonates.
methodsThis was an observational, retrospective review of conversions from dexmedetomidine to -clonidine, performed in a neonatal intensive care unit (NICU) between January 2020 and December 2021. Both initial conversion factors and those resulting after a 48-hour titration period were examined. Sedation and withdrawal scores were measured, and doses were titrated based on a standardized practice within the unit.
resultsA total of 43 dexmedetomidine to clonidine conversions were included. The median (IQR) dexmedetomidine dose prior to conversion was 17.4 (11.3-24.0) mcg/kg/day (0.7 mcg/kg/hr) and the median (IQR) enteral clonidine dose post titration was 7.8 (4.7-9.3) mcg/kg/day (2 mcg/kg every 6 hours). This equated to a post-titration conversion factor of approximately 0.42. All neonates had also received opioid infusions while on dexmedetomidine and 60% were on concurrent opioids at the time of the clonidine conversion.
conclusionsNeonatal clinicians may find the conversion factor identified in this study a useful starting point when converting from dexmedetomidine infusion to enteral clonidine in practice and should be -reminded of the most important steps in conversions (monitoring and follow-up) owing to the variability in this patient group. More studies are needed to elucidate the impact of patient-specific factors on this -conversion process.
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