ArticleJournal of thoracic disease2024
Meta-analysis and systematic review of mediastinal cryobiopsy versus endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of intrathoracic adenopathy.
Article in Journal of thoracic disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transbronchial needle core biopsyEuropean respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Enhancing Diagnostic Yield: The Role of Endobronchial Ultrasound-Guided Cryobiopsy in the Evaluation of Mediastinal Lymphadenopathy.CHEST pulmonary · 2026Article
- Diagnostic Yield of EBUS Mediastinal Cryobiopsy Versus TBNA in Suspected Lymphoproliferative Disorders: A Prospective Multicentre Study.Respirology (Carlton, Vic.) · 2026Article
- Article
- Cryobiopsy Outperforms Fine-Needle Aspiration for Mediastinal Lymphadenopathy: A Within-Patient Diagnostic Accuracy Study and Clinical Predictors of Success.Journal of clinical medicine · 2026Article
- Superior Diagnostic Yield of EBUS-Guided Cryobiopsy over Needle Aspiration in Isolated, Mass-Negative Mediastinal Lymphadenopathy: A Prospective Within-Patient Study.Diagnostics (Basel, Switzerland) · 2026Article
- Comparative Efficacy of Transbronchial Needle Aspiration and Cryobiopsies in Thoracic Disorders: A Systematic Review and Meta-Analysis for Optimal Diagnostic Efficacy.Life (Basel, Switzerland) · 2026Review
- The vanishing lesion: A procedural clue to pneumothorax during endobronchial ultrasound.Lung India : official organ of Indian Chest Society · 2026Article
- Approach to mediastinal cytopathology: a diagnostic overview.Mediastinum (Hong Kong, China) · 2026Review
- Transbronchial Mediastinal Cryobiopsy Diagnostic Yield and Perioperative Patient Management: A Single Tertiary Center Experience.Thoracic research and practice · 2025Article
- Clinical Utility of Endoscopic Ultrasound (EUS) and Endobronchial Ultrasound (EBUS) in the Evaluation of Mediastinal Lymphadenopathy.Diagnostics (Basel, Switzerland) · 2025Review
- Performance of Endobronchial Ultrasound-Guided Cryobiopsy in Diagnosing Thoracic Disorders and Its Role in Next-Generation Sequencing for Non-Small-Cell Lung Cancer.Pulmonary medicine · 2025Article
- Endoscopic ultrasound with bronchoscope-guided transesophageal cryobiopsy: A case series with technical insights, key enablers, and review of literature.Respirology case reports · 2024Article
- Diagnostic modalities in the mediastinum and the role of bronchoscopy in mediastinal assessment: a narrative review.Mediastinum (Hong Kong, China) · 2024Review
- The New Ice Age: Cold Applications in Pulmonology.Open respiratory archivesArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endobronchial ultrasound (EBUS)-guided mediastinal/hilar cryobiopsy (MedCryoBx) is a relatively new modality, being combined with EBUS-transbronchial needle aspiration (TBNA) to improve yield in the diagnosis of intrathoracic adenopathy. This meta-analysis aims to investigate the diagnostic yield of MedCryoBx versus EBUS-TBNA for intrathoracic adenopathy. Methods: We conducted a systematic search using Google Scholar, Embase, and PubMed/MEDLINE for studies about a diagnosis of intrathoracic adenopathy using MedCryoBx and EBUS-TBNA. Two authors separately reviewed studies for inherent bias using the Quality Assessment Data Abstraction and Synthesis-2 (QUADAS-2) tool. Inverse Variance weighting for random effects methodology was used for meta-analysis. Pooled diagnostic yields overall and for subgroups were estimated. Complications of MedCryoBx were reviewed. Results: Ten studies with 844 patients undergoing either biopsy procedure were in the final analysis. A total of 554 patients underwent MedCryoBx and 704 patients EBUS-TBNA. Meta-analysis showed a pooled diagnostic yield of 91% (504 of 554) for MedCryoBx and 81% (567 of 704) for EBUS-TBNA, with odds ratio (OR) of 2.5 [95% confidence interval (CI): 1.6 to 3.91; P<0.001], with I Conclusions: MedCryoBx is a very promising tool for the diagnosis of intrathoracic adenopathy. It has improved diagnostic yield over EBUS-TBNA in benign and possibly lymphoproliferative diseases, but less so in lung cancer. The complication rates with MedCryoBx are comparable to EBUS-TBNA.
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