ArticleQuantitative imaging in medicine and surgery2024
Deep learning-based detection of primary bone tumors around the knee joint on radiographs: a multicenter study.
Article in Quantitative imaging in medicine and surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Performance comparison and future perspectives of deep learning and classical machine learning in bone tumor applications: a systematic review (2019-2025).BMC medical informatics and decision making · 2026Pooled it
- Hybrid EfficientNet B4 and SVM framework for rapid and accurate bone cancer diagnosis from X-rays.Scientific reports · 2026Article
- Bone-CNN: A Lightweight Deep Learning Architecture for Multi-Class Classification of Primary Bone Tumours in Radiographs.Biomedicines · 2026Article
- Tracking temporal progression of benign bone tumors through X-ray based detection and segmentation.Scientific reports · 2025Article
- Deep learning-based fusion of nuclear segmentation features for microsatellite instability and tumor mutational burden prediction in digestive tract cancers: a multicenter validation study.Briefings in bioinformatics · 2025Article
- Generative artificial intelligence, large language models and ChatGPT in musculoskeletal Oncology: Current applications and future potential.Journal of clinical orthopaedics and trauma · 2025Article
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13 authors.
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Abstract
Background: Most primary bone tumors are often found in the bone around the knee joint. However, the detection of primary bone tumors on radiographs can be challenging for the inexperienced or junior radiologist. This study aimed to develop a deep learning (DL) model for the detection of primary bone tumors around the knee joint on radiographs. Methods: From four tertiary referral centers, we recruited 687 patients diagnosed with bone tumors (including osteosarcoma, chondrosarcoma, giant cell tumor of bone, bone cyst, enchondroma, fibrous dysplasia, etc.; 417 males, 270 females; mean age 22.8±13.2 years) by postoperative pathology or clinical imaging/follow-up, and 1,988 participants with normal bone radiographs (1,152 males, 836 females; mean age 27.9±12.2 years). The dataset was split into a training set for model development, an internal independent and an external test set for model validation. The trained model located bone tumor lesions and then detected tumor patients. Receiver operating characteristic curves and Cohen's kappa coefficient were used for evaluating detection performance. We compared the model's detection performance with that of two junior radiologists in the internal test set using permutation tests. Results: The DL model correctly localized 94.5% and 92.9% bone tumors on radiographs in the internal and external test set, respectively. An accuracy of 0.964/0.920, and an area under the receiver operating characteristic curve (AUC) of 0.981/0.990 in DL detection of bone tumor patients were for the internal and external test set, respectively. Cohen's kappa coefficient of the model in the internal test set was significantly higher than that of the two junior radiologists with 4 and 3 years of experience in musculoskeletal radiology (Model Conclusions: The DL model achieved good performance in detecting primary bone tumors around the knee joint. This model had better performance than those of junior radiologists, indicating the potential for the detection of bone tumors on radiographs.
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